- Series: Statistics and Computing
- Paperback: 530 pages
- Publisher: Springer; 2000 edition (April 15, 2009)
- Language: English
- ISBN-10: 1441903178
- ISBN-13: 978-1441903174
- Product Dimensions: 6.1 x 1.2 x 9.2 inches
- Shipping Weight: 2.1 pounds (View shipping rates and policies)
- Average Customer Review: 7 customer reviews
- Amazon Best Sellers Rank: #2,133,541 in Books (See Top 100 in Books)
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Mixed-Effects Models in S and S-PLUS (Statistics and Computing) 2000th Edition
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From the Back Cover
This paperback edition is a reprint of the 2000 edition.
This book provides an overview of the theory and application of linear and nonlinear mixed-effects models in the analysis of grouped data, such as longitudinal data, repeated measures, and multilevel data. A unified model-building strategy for both linear and nonlinear models is presented and applied to the analysis of over 20 real datasets from a wide variety of areas, including pharmacokinetics, agriculture, and manufacturing. A strong emphasis is placed on the use of graphical displays at the various phases of the model-building process, starting with exploratory plots of the data and concluding with diagnostic plots to assess the adequacy of a fitted model. Over 170 figures areincluded in the book.
The NLME package for analyzing mixed-effects models in R and S-PLUS, developed by the authors, provides the underlying software for implementing the methods presented in the text, being described and illustrated in detail throughout the book.
The balanced mix of real data examples, modeling software, and theory makes this book a useful reference for practitioners using mixed-effects models in their data analyses. It can also be used as a text for a one-semester graduate-level applied course in mixed-effects models. Researchers in statistical computing will also find this book appealing for its presentation of novel and efficient computational methods for fitting linear and nonlinear mixed-effects models.
José C. Pinheiro is a Senior Biometrical Fellow at Novartis Pharmaceuticals, having worked at Bell Labs during the time this book was produced. He has published extensively in mixed-effects models, dose finding methods in clinical development, and other areas of biostatistics.
Douglas M. Bates is Professor of Statistics at the University of Wisconsin-Madison. He is the author, with Donald G. Watts, of Nonlinear Regression Analysis and Its Applications, a Fellow of the American Statistical Association, and a former chair of the Statistical Computing Section.
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This is a useful book for using the nlme and lme4 packages in R, as it covers the theory of mixed effects models and provides practical examples of their analysis in S. The code can be used in R, as I have been doing, although the output may differ somewhat from that provided in the book.
If you wish to learn about mixed effects models, and in particular if you are using R, I recommend this book.
Bates is an expert on nonlinear regression and hence the emphasis on the nonlinear models as well as the linear ones. These models are very useful for handling repeated measures data with missing observations. Such data often arise in clinical trials and these models have been used to do the intnt to treat analysis that is often required in regulatory submissions to the FDA, Also some variables are quite naturally modelled as a random effects component in the model.The specific clinical site for investigators in a multi-site trial is one common example.
I strong recommend this book to whom needs nonlinear mixed models of longitudinal data in R.
Every statistician should has this book.
A good example of its beginner unfriendliness is the first example(!) to have a vector within a dataframe of exactly the same name. Not a good idea in a text book. You would have thought the editor would have had something to say about that.