Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics 3rd Edition

by Lauren Pecorino (Author)

71 ratings

ISBN-13: 978-0199577170

ISBN-10: 019957717X

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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
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Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result.
Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms that underpin the regulation of cell replication, and what is happening at the molecular level when these fail.

The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms that drive cancer is leading to the development of new targeted therapeutic
agents.

Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer.

Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies.

Written with students in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject--and an appreciation of
how a theoretical understanding can be transformed into therapeutic benefit.

The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease--and uncover possible solutions for its effective control.

COMPANION WEBSITE (www.oup.com/uk/orc/bin/9780199577170)

For students:
* Hyperlinks to primary literature articles featured in the text
* News feeds relevant to cancer biology, drawn from a variety of publications
* A web link library, giving access to relevant online resources

For instructors:
* Downloadable figures from the book
* A Test Bank of questions, with feedback linked to the book, for use in formative or summative assessment (password-protected)

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Editorial Reviews

Review

" The book's special appeal lies in its ability to stimulate both learning and investigation, which I hope will be its lasting legacy." Dr Graham Godfrey -The Biologist.

About the Author

Lauren Pecorino, University of Greenwich.

Product details

Publisher ‏ : ‎ Oxford University Press; 3rd edition (June 18, 2012)
Language ‏ : ‎ English
Paperback ‏ : ‎ 352 pages
ISBN-10 ‏ : ‎ 019957717X
ISBN-13 ‏ : ‎ 978-0199577170
Item Weight ‏ : ‎ 1.57 pounds
Dimensions ‏ : ‎ 9.6 x 0.8 x 7.4 inches

Best Sellers Rank: #2,157,319 in Books (See Top 100 in Books)
- #593 in Oncology (Books)
- #678 in Pathology (Books)
- #1,103 in Molecular Biology (Books)

Customer Reviews:
71 ratings

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Lauren Pecorino

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Lauren Pecorino was born in New York City. She received her PhD from the State University of New York at Stony Brook in Cell and Developmental Biology. She crossed the Atlantic to carry out a postdoctoral tenure at the Ludwig Institute for Cancer Research, London. She is a Professor (Cancer Biology)at the University of Greenwich. Here she developed a course called: Cancer Biology and Therapeutics. The teaching of this course motivated her to write the university textbook called ‘The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics’, published by Oxford University Press. The book is unique in that every chapter links basic cancer biology to its application towards the development of new therapeutics- an area that motivates students to learn. It also translates important pathways into easy-to-understand diagrams. The text has been translated into several languages and is now in its 5th edition. Lauren has given many international lectures on cancer. Feedback on the textbook posted on Amazon from a cancer patient drove her to write a book on cancer for a wider audience called ‘Why Millions Survive Cancer: the successes of science’. This book is for non-specialists who are interested in the science of cancer and also well being. She hopes it will make a difference to your life.

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Rogera Sauterer

Good overview for advancecd undergraduates and beginning graduate students

Reviewed in the United States on January 6, 2014

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Lauren Pecorino overlapped with me as graduate students at SUNY-Stony Brook where she was doing research on molecular aspects of cancer. I was quite pleased that her book was available when I taught a short course on cancer biology for our beginning graduate students. Though not totally without flaws, Pecorino's book fits the bill for a short upper-level undergraduate or beginning graduate course on the cell and molecular mechanisms of cancer.
The strengths of this book is that it is relatively short (250 pages or so), explains basic concepts clearly, requiring only a basic background in cell and molecular biology, includes key references at the end of each chapter, and includes some clinical correlations and discussions of new targeted therapies utilizing the mechanisms described in each chapter. Pecorino's book is divided into clear, self-contained chapters on various mechanisms of cancer, including genetic mutations and loss of DNA repair mechanisms, major tumor supressors such as Rb and P-53 and their roles in regulation of cell division, signaling pathways and defects in them, epigenetic mechanisms and defects, and metastasis mechanisms. Each chapter explains the basic mechanisms and concepts clearly and succinctly, then goes on to show how these mechanisms are involved in cancer, finishing with descriptions of new, targeted therapy approaches that affect these mechanisms.
The main flaws, though minor, of this book is that there needs to be more discussion on epigenetic mechanisms and cancer, since it is such a rapidly-growing field, and placing all the major signaling pathways important in cancer genesis in a single chapter rather than scattering them in several chapters. Aside from these minor issues, I find this book very well-suited for a short course on the cellular and molecular mechanisms of cancer, which should interest advanced students in cell, developmental and molecular biology as well as those aspiring to clinical careers. It is considerably better than many other texts on the market that are intended for the same audiences.

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discerning consumer

great textbook for folks with a science or medicine background or interest

Reviewed in the United States on January 6, 2013

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Please read Dr. McGarty's excellent review for details about this really well-written textbook. I'm an internist with an interest in cancer and my oncology training is 25 years old at this point. So, I wanted some "real science" connected to some "real medicine" and this text was perfect for that. To be honest, you need to read this with a white board or paper nearby and approach it as a student would. When she says, take a minute to see if you can diagram this pathway, better do it, because otherwise the progressions will lose you. The author has written a second book- Why Millions Survive Cancer that may be a better introduction for non-health care professionals actually. Both books are excellent; if you are an accountant with an interest in cancer, I would start with her second text "...Survive Cancer" and move to this one next. For health care folks with a serious interest, this text is truly wonderful (for all the reasons stated so eloquently in Dr. McGarty's review.

3 people found this helpful

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Dr. Terrence McGartyTop Contributor: Photography

Third Edition is Superb Addition to any Library

Reviewed in the United States on December 6, 2012

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The introductory book by Pecorino is a superb introduction to the molecular issues related to cancer. The book presents a highly readable and enlightening summary of many of the key issues of pathways and cancer. It can be used as a first step in this exciting field.

The style is straightforward and all encompassing. It can be used by any student who is approaching the field for the first time and it can be an update refresher for those who may have been exposed in the past. It is not of the level of Weinberg but it does address all of the salient issues in a level of depth that allows for a ready follow on using the more in depth texts.

I have used the second edition in the past as a guide to writing materials and obtaining a grasp of broad concepts and issues. The third edition is a superb follow on to the last one.

Chapter 2 is a brief summary of DNA and its interaction in carcinogenesis. Chapter 3 is gene expression. I especially liked the discussion on epigenetic regulation which is a simple and direct coverage of this increasingly important area. Section 3.4 discusses epigenetics and cancer which is current and a critical topic.

Chapter 4 is on growth factor signalling. I typically like to look at the process as a complete system, starting with a statement and model of ligands, receptors, cytoplasmic pathways and then transcription. Although this is done in parts the presentation as an integrated whole is important. The kinase cascades are discussed. One of the general weaknesses of many presentations is the discussion of just how do these proteins interact, at binding sites, and then whether or now one should use kinetic models applicable more appropriately to higher concentrations. Perhaps that goes into more depth than would be necessary but I find it useful for students who have the chemistry background to grasp the concepts. The diagrams are useful and provide constructural understanding.

Chapter 5 discusses the cell cycle. The CDKs are the heart of much of this portion of mitotic growth and the author covers them in adequate detail.

Chapter 6 discusses growth inhibition and tumor suppressor genes. The heart of this is the discussion of p53 the classic control gene. I would have liked a more detailed discussion of ubiquitin and also of the MDM proteins but again for the level of the text's audience the introduction is more than adequate.

Chapter 9 on metastasis is simply stated and gives the reader a somewhat detailed overview. My only critique is that it would have been useful to have a bit more detailed discussion of the ECM, extracellular membrane, its structure, elements, and functions, with a separate subsection. The author does refer to it and provides a reasonable first step.

The author blends therapeutics very well across the presentations showing how progress is made. I would have like some discussion of pathway dynamics. There are many books which detail these approaches but perhaps again this is a bit too much. One final nit is that the experimental basis of the results would be useful to have been added, for example by an Appendix.

Overall the book is a superb addition to anyone's library on molecular cancer genomics.

7 people found this helpful

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s. berger

a fine overview

Reviewed in the United States on May 14, 2014

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As an oncologist I found this book to be timely, well-written, and informative. there are many illustrations to accompany the discussions. I had the first edition of this book and enjoyed that; when I saw that a second edition was available I snapped it up. Turned out the academic center at which I worked recommended it as the basic text for their lectures in molecular biology. It is a useful adjunct for students and physicians, though researchers are probably familiar with the material. Highly recommended.

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Top reviews from other countries

Cagsy

This is a fantastic Book

Reviewed in the United Kingdom on November 19, 2013

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I ordered this book from "the Full Monty" but never received it. I did however borrow it from the university library whilst waiting for the ordered one to arrive. A really good book about the subject. very clear explanations.

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Sibel Sahin

Brilliant.

Reviewed in the United Kingdom on April 29, 2020

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Passed the exam with flying colours - 100% recommend :)

Amazon Customer

Good

Reviewed in the United Kingdom on September 20, 2018

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Good for the price and timely

Amazon Customer

Very modern book, including the most recent theory about ...

Reviewed in the United Kingdom on August 4, 2016

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Very modern book,including the most recent theory about cancer therapies.

SASA

Four Stars

Reviewed in the United Kingdom on June 4, 2015

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It is good

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