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Molecular Biology of the Gene, Fifth Edition 5th Edition

4.4 out of 5 stars 8 customer reviews
ISBN-13: 978-0805346350
ISBN-10: 080534635X
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Editorial Reviews

From the Back Cover

Introduction to BotanyThe long-awaited new edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline, giving both historical and basic chemical context. Divided into four parts: Genetics and Chemistry, Central Dogma, Regulation, and Methods. For college instructors, students, and anyone interested in molecular biology and genetics.

About the Author

James D. Watson was Director of Cold Spring Harbor Laboratory from 1968 to 1993 and is now its President. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth edition. These were published in 1965, 1970, 1976, and 1987 respectively. Watson has also been involved in two other textbooks: he was one of the original authors of Molecular Biology of the Cell and is also an author of Recombinant DNA: a short course.Tania A. Baker is the Whitehead Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdoctoral research in the laboratory of Dr. Kiyoshi Mizuuchi at the National Institutes of Health, studying the mechanism and regulation of DNA transposition. Her current research explores mechanisms and regulation of genetic recombination, enzyme-catalyzed protein unfolding, and ATP-dependent protein degradation. Professor Baker received the 2001 Eli Lilly Research Award from the American Society of Microbiology and the 2000 MIT School of Science Teaching Prize for Undergraduate Education. She is co-author (with Arthur Kornberg) of the book DNA Replication, Second Edition.Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Assistant Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMBÐSchering Plough Scientific Achievement Award, and the Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT in 1998. Alexander Gann is Editorial Director of Cold Spring Harbor Laboratory Press, and a faculty member of the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. He received his B.Sc in microbiology from University College London and a Ph.D. in molecular biology from The University of Edinburgh in 1989. His graduate research was carried out in the laboratory of Noreen Murray and focused on DNA recognition by restriction enzymes. He did postdoctoral research in the laboratory of Mark Ptashne at Harvard, working on transcriptional regulation, and that of Jerem
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Product Details

  • Hardcover: 830 pages
  • Publisher: Cold Spring Harbor Laboratory Press; 5th edition (December 3, 2003)
  • Language: English
  • ISBN-10: 080534635X
  • ISBN-13: 978-0805346350
  • Product Dimensions: 11.2 x 1 x 8.4 inches
  • Shipping Weight: 4 pounds
  • Average Customer Review: 4.4 out of 5 stars  See all reviews (8 customer reviews)
  • Amazon Best Sellers Rank: #190,686 in Books (See Top 100 in Books)

Customer Reviews

Top Customer Reviews

Format: Hardcover
Some books are just very well written-this is one of them!

I like that they leave space in the margin to write notes. Organized more like a book you can read in chapters compared to the Lewin Genes text. Concise and up to date.

Good disc included with lots of great animations.
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Format: Hardcover Verified Purchase
I am supplementing this book with my molecular biology class and I only needed the disk part this was the best priced and it had the disk as others that were way more priced didn't have the disk. I was still worried after I ordered the book as to wheather it really did have the disk or not so I sent an email to the seller and received a quick response! Awesome! However I was stilled worried about the condition of the disk. I received this book promptly! The disk and book was in great condition! I am happy and will recommend to anyone!
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This book strikes the perfect balance of clarity and brevity. The explanations are thorough without being verbose, and the book does not try to go out of its way to be a comprehensive guide to biochemistry or cell biology, which is not its subject matter. Instead what one gets are clear, focused, easy-to-read explanations of the core of molecular biology (replication, transcription, translation, DNA damage and maintenance) that are essential for anyone working in the life sciences. Additionally, the illustrations are eminently clear and do not contain any unnecessary information.

One major complaint I have is the illustrations for phage lambda gene regulation. The DNA is shown as a single cylinder, but this is misleading because genes reside on both strands. It is important to remember the directionality of genes and promoters in this system, and condensing all information onto a single strand temporarily inhibited my understanding of this section.

Also, the next edition introduces a new chapter on RNA and its role in gene regulation - i.e. riboswitches, RNAi, and RNA silencing. This material is completely absent from this edition since it is so new.

Overall this is the finest example of a textbook I have come across in my undergraduate career. I always came away from reading it with a clear picture of what was being described. The does one thing and does it well - clear descriptions of molecular biology.
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Format: Hardcover Verified Purchase
"Molecular Biology of the Gene," James Watson et. al, 5th Edition, CSHL Press, NY 2004, ISBN 0-8053-4635-X, HC 732 pages, includes Preface, Index & inter-active CD-ROM & Website. 11 1/4" x 8 3/4".

J.D. Watson authored first three editions (1965-'76), co-authored 4th ('87) & this 5th ('04) with Baker, Bell, Gann, Levine & Losick. CD works in Windows, but Mac OS X needs Classic for some sections (CHIME). This treatise has 21 chapters divided into 5 major parts: I-Chem.& Genetics, II-Genome Maintenance, III-Genome Expression, IV-Regulation and V-Methodologies.

The discourse best assumes readers to have both core & some advanced study in biology, chemistry, physics & genetics. It is a tutorial & reference manual with detailed covering of history of genetics, Mendelian heredity, elucidation & clarificaion of double helix, Crick's central dogma 1956, genetic code, weak & high-energy bonds, protein structure, conformation, modularity & domains, allostery, topologies, RNA structure, chromosomal sequence & diversity, duplication, chromatin structure & regulation, nucleosome assembly, DNA polymerase, binding & unwinding, replication error & repairs, DNA damage, recombination, transposition, transciption, splicings, shuffling, ribosomes, gene regulation in pro- & eu-karyotes, embryogenesis of Drosophila, genome evolution & methodologies for phage, bacteria, yeast, fly & mouse.

A formidable and now classic text fittingly entrusted to an elite working group in the US, UK and Canada. Most comforting is the liberal use of diagrams on essentially every page & the interactive CD.
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