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Molecular Biology of the Gene, Fifth Edition 5th Edition
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Top Customer Reviews
I like that they leave space in the margin to write notes. Organized more like a book you can read in chapters compared to the Lewin Genes text. Concise and up to date.
Good disc included with lots of great animations.
One major complaint I have is the illustrations for phage lambda gene regulation. The DNA is shown as a single cylinder, but this is misleading because genes reside on both strands. It is important to remember the directionality of genes and promoters in this system, and condensing all information onto a single strand temporarily inhibited my understanding of this section.
Also, the next edition introduces a new chapter on RNA and its role in gene regulation - i.e. riboswitches, RNAi, and RNA silencing. This material is completely absent from this edition since it is so new.
Overall this is the finest example of a textbook I have come across in my undergraduate career. I always came away from reading it with a clear picture of what was being described. The does one thing and does it well - clear descriptions of molecular biology.
J.D. Watson authored first three editions (1965-'76), co-authored 4th ('87) & this 5th ('04) with Baker, Bell, Gann, Levine & Losick. CD works in Windows, but Mac OS X needs Classic for some sections (CHIME). This treatise has 21 chapters divided into 5 major parts: I-Chem.& Genetics, II-Genome Maintenance, III-Genome Expression, IV-Regulation and V-Methodologies.
The discourse best assumes readers to have both core & some advanced study in biology, chemistry, physics & genetics. It is a tutorial & reference manual with detailed covering of history of genetics, Mendelian heredity, elucidation & clarificaion of double helix, Crick's central dogma 1956, genetic code, weak & high-energy bonds, protein structure, conformation, modularity & domains, allostery, topologies, RNA structure, chromosomal sequence & diversity, duplication, chromatin structure & regulation, nucleosome assembly, DNA polymerase, binding & unwinding, replication error & repairs, DNA damage, recombination, transposition, transciption, splicings, shuffling, ribosomes, gene regulation in pro- & eu-karyotes, embryogenesis of Drosophila, genome evolution & methodologies for phage, bacteria, yeast, fly & mouse.
A formidable and now classic text fittingly entrusted to an elite working group in the US, UK and Canada. Most comforting is the liberal use of diagrams on essentially every page & the interactive CD.
Most Recent Customer Reviews
I got this book to assist for my prep for the Biochemistry GRE - I know a lot about Biology. So this is a great Book - First, It is very readable - I was surprised I was not able... Read morePublished on September 18, 2006 by J. Elliott
This book is an awesome teaching guide but the real prize goes to the CD and animations. Where a subject might be a bit hazy in the text, the flash animations on the CD are clear... Read morePublished on March 17, 2006 by R. Literman
Buy this book if you are really unintelligent and knows virtually nothing about biology. Really. if you are the person who wants to learn, find an alternative book.Published on September 23, 2005 by John Doe