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Louis J. Ignarro

NO More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse--Heart Disease and Strokes Paperback – January 24, 2006

by Louis Ignarro (Author)

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Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well.

NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor.

The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.

Print length

272 pages
Language

English
Publication date

January 24, 2006
Dimensions

8.5 x 0.85 x 8.2 inches
ISBN-10

0274872951
ISBN-13

978-0312335823
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Editorial Reviews

Review

“The discovery of Nitric Oxide by Lou Ignarro, and the role that it plays in reducing the risk of cardiovascular disease, is as important as the discovery of penicillin and insulin.” ―David Heber, M.D., Ph.D., Director, UCLA Center for Human Nutrition

About the Author

Dr. Louis J. Ignarro is a Distinguished Professor of Pharmacology at the UCLA School of Medicine. He has developed a supplement called Niteworks that is distributed by Herbalife. He won the Nobel Prize in Medicine in 1998 for his research on Nitric Oxide.

Product details

ASIN ‏ : ‎ 0312335822
Publisher ‏ : ‎ St. Martin's Griffin; First edition (January 24, 2006)
Language ‏ : ‎ English
Paperback ‏ : ‎ 272 pages
ISBN-10 ‏ : ‎ 0274872951
ISBN-13 ‏ : ‎ 978-0312335823
Item Weight ‏ : ‎ 8.5 ounces
Dimensions ‏ : ‎ 8.5 x 0.85 x 8.2 inches

Best Sellers Rank: #292,055 in Books (See Top 100 in Books)
- #173 in Cardiovascular Diseases (Books)
- #181 in Cardiology (Books)
- #205 in Heart Disease (Books)

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414 ratings

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Louis J. Ignarro

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In 1998, Dr. Louis Ignarro won the Nobel Prize for Medicine, (along with Robert F. Furchgott and Ferid Murad), for his research discoveries showing the powerful ability of nitric oxide (or NO) to improve cardiovascular health and prevent heart disease. His ground-breaking work— the basis for his 2005 best-selling book, NO More Heart Disease— established Dr. Ignarro as perhaps the world’s leading authority on the nutritional approach to cardiac wellness, along with making possible the development of Viagra.

He holds a Ph.D. in pharmacology, is a distinguished professor of pharmacology at UCLA, and is a part-time professor at King Saud University in Riyadh, Saudi Arabia. Dr. Ignarro has spent more than 30 years as a research scientist; seeking to understand the incredible role that nitric oxide plays in fostering optimal human health. One of his most important discoveries was that antioxidants, which reduce cell damage fromfree radicals, also increase nitric oxide levels by protecting blood vessel walls—which secrete nitric oxide—from damage.

He has received countless awards in addition to his Nobel Prize, including the 2008 Distinguished Scientist Award from the American Heart Association and the 2007 Medal of Merit from the International Academy of Cardiovascular Sciences. He edits the journal Nitric Oxide: Biology and Chemistry, sits on numerous scientific advisory boards, and travels the world speaking to professional and lay audiences about the incredible power of nitric oxide.

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H. Zhang

Quite educational, but short of rigor

Reviewed in the United States 🇺🇸 on August 6, 2012

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I bet most people have no idea who Dr. Ignarro is, but know the drug of which he is the father - Viagra. Ignarro won the 1998 Nobel Prize in Physiology or Medicine shared with two other scientists for his discovery of the signaling properties of nitric oxide (NO).

The journeys of Nobel Laureates usually are fascinating and inspiring, and Ignarro's is no exception. A son of an immigrant carpenter, he started to have an intense interest in chemistry at a very early age leading to his career in pharmacology. His focus, persistence and tenacity paid off eventually. The biography part is very short because this book is primarily about a personal health program centered on NO.

I am glad to see the author frankly describing the difficulty in getting his discovery to be accepted. This is fairly common in the scientific community which, contrary to what many lay people think, is often resistant to new ideas except if they are from big names or labs. He discovered the vasodilation effect of nitric oxide (NO). When he presented his work showing that endothelium-derived relaxing factor (EDRF), discovered by his co-laureate Robert Furchgott, is actually NO at a conference, the conference attendees treated the work as a joke. His paper was rejected by multiple major scientific journals. He had difficulty in obtaining fund from the NIH for his research in NO for a long time.

Though I did not expect this book to be a scholarly text, I was still surprised by the shortage of rigor in this book. After all, Ignarro is prominent scientist, so I expected he would make claims cautiously, and substantiate every claim with solid evidences.

For books written by prominent scholars like Ignarro, laypeople may be afraid of too much / too deep scientific information for them to comprehend. This book, in my opinion, is the opposite - too little scientific data while too many big statements. The book claims NO is regarded as the most significant molecule in the body. I am not sure in what sense NO is the most significant. More significant than H2O? The book has a long list of the benefits of NO. I thought Chapter 3. The Science of NO would be the most important chapter, and provide the mechanism and evidence to support these benefits. To my surprise, it is the shortest chapter providing nothing but some statements and most superficial account of NO. The book frequently uses selected testimonials from NO supplement customers; this gives a strong commercial taste.

I am wondering if some statements are backed by research data. For example, a major claim of the book is that NO fights atherosclerosis, but it does not provide any studies showing how NO does it.

The book cites many studies, but often omits important numbers. For example, it mentions a small study of Mayo Clinic on the benefit of L-arginine for coronary artery disease. It is disappointing, and somewhat disturbing that the citation does not mention how significant the improvement is (e.g. the percentage of disease reduction).

His use of garden hose as an analogy of the vascular system to explain high blood pressure could confuse people. It explains only the systolic pressure. Many hypertensions are due to high base pressures (i.e. diastolic pressures). A better analogy is a balloon filled with water. The pressure is determined by the amount of the water and the elasticity of the balloon. Our body adjusts the amount of blood via the kidney to control our blood pressure. This is also how diuretics lower the blood pressure.

The mission of the book is advocating Ignarro's three-part program: 1.NO boosting supplements; 2. NO boosting nutrition; 3. NO boosting fitness. The latter two parts are consistent with common sense. The key part is the supplements - L-arginine and L-citrulline.

The essence of how the supplements work is L-citrulline => L-arginine => NO. NO is unstable, and can be toxic if administered directly. L-arginine is stable, and can be converted to NO in the body safely. The book says: "L-citrulline combines with L-arginine to create a synergistic effect, and it is therefore critical for you to include L-citrulline in your supplement program.", but it does not substantiate this claim with scientific studies. Some have questioned the significance of L-citrulline in this supplement regimen. L-citrulline is converted to L-arginine in the body. If this is all L-citrulline does, there is little reason to include L-citrulline.

Though the book mentions repeatedly a few well known sources of supplements, it does briefly and clearly promotes the author's invention as the best option - Nite-works that has all the supplements in the right proportion.

Though I applaud Dr. Ignarro's effort to educate people about NO and advocate fitness and balanced nutrition, I would not recommend this book to anyone who does not tend to read critically.

16 people found this helpful

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Another heart book: steak fan's choice

Reviewed in the United States 🇺🇸 on August 24, 2009

Verified Purchase

Of the five popular heart books I've recently picked off Amazon, Dr. Ignarro's will no doubt have an immediate appeal to many readers. He permits steaks, sanctions some other commonly forbidden foods, and pushes pills as a cure for heart disease, which he ascribes to insufficient nitric oxide (hence, the constant use of the acronym N.O., including the somewhat tedious slogan "Say Yes to NO"). The book can at times seem a bit quirky: like most of these writers the author doesn't pass up a chance to remind us of his credentials and accomplishments; the chapters and statements can be annoyingly repetitious, written as though a previously stated point were being made for the first time; the author provides an e-mail address and encourages the reader to write, then adds he expects more mail than he or his staff will have time to reply to. The inserts containing testimonies by "successful" Ignarro program followers somehow seem less reassuring when the source is a 32-year-old. Finally, the author can be exasperatingly quick to throw in numerous "in additions." In other words, the recommendation for 20 minutes of moderate exercise three days per week comes with inserted testimonials by marathon runners along with an insistence that, in addition to those three days, another two days must be committed to weight training (curiously the author devotes no more than a single paragraph to describing these exercises, even while proclaiming them as another essential source of N.O. and later claiming that he indeed has described an exercise program for the reader).

But perhaps of greatest interest to most readers will be the "magic bullet"--the supplement that will ensure sufficient production of nitric oxide to accomplish the promise of the book's not-so- modest title. And here's where the claim that a single supplement is the key begins to take on leaks with the potential to sink the ship. There are actually six supplements on the "must take" list, chief among them the amino acid arginine which, when taken with the complementary, or "synergistic," amino acid citrulline, will enable the body to manufacture enough N.O. to keep things freely flowing in refreshed if not renewed arteries. And the six supplements are to be taken in fairly generous quantities and in megapotencies (anything less than 4 grams will nullify any benefit)--along WITH your prescribed drugs (the author blithely asserts his N.O. regimen will "boost" the effects of your statin drugs). But soon the reader is encouraged to sample every other vitamin and trendy supplement you may or may not have heard of--from garlic to resvinatrol/resveratrol to dark chocolate to soy sauce to green tea to krill to taurine ("Try it: see if you like it" is a frequent phrase--somewhat strange in reference to a supplement that is unlikely to have anything resembling an overnight effect. More importantly, a reader might be forgiven for wondering whatever happened to the initial emphasis on the miraculous synergy of just two carefully measured products? By the end of the book (and dozens of supplements later), the author predicts that all of these vitamins and compounds will be imminently available in "mega-cardiovascular" dosages.

And what's the reward for agreeing to become an obsessive pill swallower and walking chemical plant? Assuming you can tolerate all this stuff (I can't even handle ginseng) and have some quality of life remaining along with a healthy heart, you're allowed to eat red meat and fats (in moderation). But it's questionable whether Dr. Ignarro's book is all that less strict than Dr. Esselstyn's ("Prevent and Reverse Heart Disease," which flat out forbids the consumption of any product that owes its existence to "the face of a mother"--including, of course, meat (incl. fish), milk, eggs, and oils (incl. fish oil).

At least there's something all of these guys agree on--saturated fat and free radicals are bad and omega 3 is good. But especially in the area of "degree," or "quantity," the differences among the authors are at times more conspicuous than the similarities. And it would appear that, as yet anyway, Ignarro's recommendations have not caught fire. Looking at the shelves in both a Walgreen's and a local health store, I saw no sign of either of the two "vital" amino acids. (On the other hand, there were several brands--and not on the spice shelves, mind you--of cinnamon! So obviously someone has recently penned a best-seller touting the medicinal wonders of the seasoning, which no doubt explains why, along with acai and resvanatrol, it's currently receiving valuable shelf space at your local drug or health food store.)

If you want even more pill ideas (and haven't already been bombarded by cheerleaders for CoQ10, even though Ignarro conveniently makes room for it at the end of his book), you may wish to check out Dr. Sinatra's book ("Reverse Heart Disease Now"). I'm no scientist, but the reader should be aware of a school of scientific thought that strongly questions if not categorically rejects the notion that chemicals manufactured by and comprising the human organism can efficiently be replaced through oral supplementation--the cellular "membrane barrier" simply prohibits it. Of course, there's always Dr. Devane's book ("Heart Smart"), practical, commonsensical and informative--and guaranteed to immediately throw a heart-stopping scare into even the most heedless reader. However, Dean Ornish's book ("Reversing Heart Disease"), though written in the 1990s, is still, to my mind, the most thoughtful and persuasive. At least he's able to give consideration to the possibility that the consuming isolation that is likely to characterize the existence of someone who's centering their daily existence on foods and supplements could be as harmful as the disease itself.

[Later: the url for the author's website as given in the book is inoperative. Instead, place a "dr" in front of "ignarro." Be aware that the critical N.O. supplements are available primarily through the controversial Herbalife company.]

25 people found this helpful

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Top reviews from other countries

Martin

If you read one book about vascular health..This should be it !

Reviewed in the United Kingdom 🇬🇧 on July 23, 2015

Verified Purchase

The BEST book for understanding Nitric Oxide (NO) written by one of the nobel laureates. I recommend to my clients and give a copy to my new team members. mysynergyhealth Co uk. It helped me understand that when my Dr gave the reason for my high BP as lifestyle...they actually meant Nitric Oxide deficiency...its about the right food..excercise and supplementation is the turbo. as you couldn't physically eat the amount of food required for your body to get a therapeutic effect, even if you had the money and the time to prepare it.... my BP is now is in the safe zone...thankfully.
Dr Ignarro explains how L-arginine needs L-citrulline to enhance the NO production....L-arginine alone will not work the same or give the maximum benefit to your cardiovascular system. He explains why he recommends supplementation and when to take it for optimum benefit. NO is the miracle signalling molecule that can improve your vascular health, you should read the book and absorb the information that is shared within...There is a good reason that they were awarded the Nobel Prize. Martin Auckland
twitter. @mySYNERGYhealth

5 people found this helpful

Dave Hall

NO More Herat Disease

Reviewed in the United Kingdom 🇬🇧 on March 27, 2011

Verified Purchase

This book is an excellent work. Written by a Nobel Prize winner who helped discover the amazing substance that our bodies need NO or Nitic Oxide. This substance is synthasied by the Amino Acid L aginine and has helped many regain good Cardiovascular health.

The book is a plain paperpack and is very easy to read and full of very good information.

I highly recommend this book and the products that have been formulated to help lower blood pressure by making the arterail walls more flexible. A product I am now using is available in the United Kingdom and Cyprus is REJUVENAL and can be obtained through distributers in those countries.

There are other good products available in other countries that work in the same way.

Enjoy your reading...................David Hall

9 people found this helpful