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Organic Chemistry 2nd Edition

4.6 out of 5 stars 25 customer reviews
ISBN-13: 978-0199270293
ISBN-10: 0199270295
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Product Details

  • Paperback: 1264 pages
  • Publisher: Oxford University Press; 2 edition (May 4, 2012)
  • Language: English
  • ISBN-10: 0199270295
  • ISBN-13: 978-0199270293
  • Product Dimensions: 10.9 x 1.8 x 7.8 inches
  • Shipping Weight: 5.3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.6 out of 5 stars  See all reviews (25 customer reviews)
  • Amazon Best Sellers Rank: #203,146 in Books (See Top 100 in Books)

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Customer Reviews

Top Customer Reviews

Format: Paperback
Since its appearance in 2001, "Clayden" is clearly the best book that undergraduates can acquire for their preparation in Organic Chemistry. This piece of art continues its hegemony in the second edition, so there is no point in comparing this book with other books actually in the market (that's the reason for 5 stars). Therefore, this review focus on comparisons between the first and second edition.

Main changes:

1) The main change in the new edition deals with the order of topic presentation. Clearly, the new order is better, and more logically fluent. For example, conjugate addition is now grouped with nucleophilic aromatic substitution.
Each chapter ends with a "further reading" section which was so much in need. These changes would be greatly valued by teachers.

2) some chapters that appeared in the 1st ed are not included in the printed version of the 2 ed, however, it should be clear that these chapters still exist and every owner of the new edition have access to then via the companion web site

3) the problems section at the end of each chapter is no longer included in the printed version, they are included in the companion web site.

4) Only few discussions were rephrased with only modest enlargement of some discussions and deletion of others. This can be seen for example in the chapter of "organometallic chemistry" were discussion of the Buchwald-Hartwig reaction is enlarged (great!) and the Pauson-Khand reaction deleted (pity).

5) Figures and paper quality are better in the new edition. These reflects in the instructor material which basically consist of digital figures inserted in ppt for each chapter.
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Format: Paperback Verified Purchase
This is undoubtedly the best modern book for learning organic chemistry. Unlike some other books which present organic chemistry as a set of facts and reactions to be learnt and memorized, this book instead emphasizes the unifying threads between different concepts and also stresses the assimilation of those concepts through real-life applications. Common themes such as syn-anti addition, carbocations and orbital overlap tie together disparate reactions and aspects of organic chemistry.

The first edition of this book was published in 2001 and the updated edition in 2012, so the discussion in this book includes reactions and reagents that are often missing from other comparable texts. For instance the volume still provides the most complete and readable description of the Grubbs metathesis reaction that I have come across, clearly emphasizing the mechanism, the effects of different ligands and solvents and applications to complex natural products. Other reactions of paramount importance to both academia and industry which are presented in the book include the palladium-catalyzed Suzuki, Heck, and Sonogashira couplings (which were recently awarded the Nobel Prize). The Buchwald-Hartwig reaction which was not as developed in 2001 but which has since seen immense growth gets an especially detailed mention.

The volume covers the whole gamut of current organic chemistry. Apart from its modern and unifying outlook, the other feature that stands out is the way it stresses the practical relevance of all this material. Organic chemistry is really the basis of our modern way of life and the book reflects this fact. The value of almost every important reaction and reagent is demonstrated by its application to the synthesis of an important drug, polymer, food additive or agrochemical.
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Format: Paperback Verified Purchase
The quote below talks about something called Markovnikov's Rule, which is a mnemonic device taught in most organic chemistry textbooks (it references a figure with a reaction immediately below it).

"There is a traditional guideline called Markovnikov's Rule for electrophilic additions of H-X to alkenes, which can be stated as: 'The hydrogen ends up attached to the carbon of the double bond that had more hydrogens to start with.' We don't suggest you learn this rule, although you may hear it referred to. As with all 'rules' it is much more important to understand the reason behind it. For example, YOU can now predict the product of the reaction below. With all due respect, Markovnikov couldn't."

This embodies the spirit of the entire textbook. Quite simply the best.
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Format: Kindle Edition Verified Purchase
This is the best organic chemistry book I have seen. I got the 1st edition in print, and I read chapters from it whenever I needed a refresher...I use it all the time as a reference too, as well as using it for explaining concepts to others. When the 2nd edition came out, I got it for my Kindle. Works very well on a Kindle. Many chemistry/physics/math books have a problem with equations on a Kindle (and other electronic readers), but with this book they took the simple approach and the whole page image is scalable. Makes it much easier to focus in on an individual concept. It's a snap to move in, and easy to go back to full page again. Very nice. I highly recommend this book.
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I purchased this book about 1 month ago, and since then, I have worked through the first 7 chapters. Overall, I feel that this Clayden provides a very fundamental approach to explaining many of the reactions, taking a molecular orbital approach to explain why certain reactions happen or why certain functional groups are more reactive than others. Compared to most introductory organic chemistry textbooks, however, Clayden is quite difficult to understand. The authors chose to present the topics in what I feel is an illogical order (for instance, analytical techniques such as IR, NMR, and mass spec are covered in Chapter 3 and the first reactions discussed are those of the carbonyl group). As a result, this book would be very challenging for someone without prior knowledge of organic chemistry or at least a gentler introduction to the topics. Nonetheless, I feel that this is a really important book for anyone serious about learning organic chemistry, especially if it is used as a supplement to a book more oriented towards beginners (such as Organic Chemistry - David Klein which is absolutely amazing as a first introduction to the subject). Clayden delves more into the details and provides both a more in-depth explanation as well as a broader coverage of important reactions. Overall, I would certainly recommend this book but only after working through a more beginner-oriented text.
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