Frequently Bought Together
Customers Who Bought This Item Also Bought
- Behind-the-Scenes Documenatry
- Behind-the-Scenes Voice Sessions
- Deleted Scenes
- "Easter Egg" Hidden Features
- DVD-ROM "Frank's Gross Anatomy" & more
Top Customer Reviews
The scenes bounce between live acting and full animation, determined by whether we are outside or inside the body of Frank. The casting for this silly and peculiar movie was expertly chosen for both live and voice roles.
Live, we have Bill Murray as Frank, in his most disgusting character since Caddyshack. Chris Elliot plays his brother Bob, and manages to challenge Murray in the "disgusting slob" category. Murray eats a hard boiled egg that landed in monkey doodoo, and thus introduces Thrax into his body, a red-death virus determined to take over Frank and kill him. (voiced by Laurence Fishburne)
Inside of Frank, we go to the animation where Chris Rock is the voice of our hero, a white blood cell named Osmosis Jones. Jones is a detective for the City Of Frank, where William Shatner does the voice for Mayor Phlemming. Jones knows something is wrong, but the Mayor denies any illness could occur in Frank. But just to be safe, he "manually overrides" Frank and has him take a cold pill.
Meet Drix, the huge and snotty cold pill, whose voice is played by David Hyde Pierce (Frazier's brother Niles). Jones and Drix make an unlikely team as they hunt down Thrax and try to stop him from killing Frank.
Nothing is taboo here; they go to the nose and get caught up in the wave of snot when Frank's allergies act up, they travel to The Zit, Frank's hottest new club where Kidney Rock is playing (Kidd Rock), and Jones reminisces about the time he hit the "Panic Button" in Frank's stomach, causing him to vomit all over his daughter Shane's teacher.Read more ›
The plot revolves around a white blood cell named Osmosis Jones (voiced by Chris Rock) who serves as a police officer in the body of a guy named Frank (Bill Murray).
When a dastardly virus named Thrax (voiced by Laurence Fishburne) invades Frank's body, it's up to the immunity force to stop him, and Ozzy is teamed up with a cold tablet named Drixobensomedaphedramine, or Drix for short (voiced by the always-wonderful David Hyde Pierce).
Meanwhile, the pompous blood cell politician in charge of Frank's body, Mayor Phlegmming (voiced by William Shatner), is desperate to win the next election, but he is obviously doing a sub-par job of running Frank's body. His aide (and Ozzy's love interest), Leah, is voiced by Brandy Norwood.
This movie is very amusing in some places, but I had to deduct one star because it is, on occasion, REALLY DARN GROSS. I had to turn my head away from the screen in some places. However, this is by no means a bad movie. I personally consider David Hyde Pierce's portrayal of Drix to be one of the best things in the film (if not the very best), especially when Drix busts a secret mob meeting at a disco and utters the following line, doing some dance steps as he speaks:
"Attention, germs, you are surrounded. Uh-huh, uh-huh. Uh-huh, uh-huh, SURROUNDED!". Trust me, it's worth seeing just for that part.
Overall, Osmosis Jones is definitely worth seeing, and it could also be used to teach an anatomy lesson, because it's very accurate. Just watch out for the gross bits.
This is the story of a guy named Osmosis Jones, a white blood cell voiced by Chris Rock. He lives inside the body of Frank, a slobby zookeeper who's body is likened to a city: it has it's dump (guess where), power plant (heart), ghetto (liver), and even natural disasters (cramps and sicknesses.) So when Frank injests a hard boiled egg that has been in the mouth of a monkey and on the ground, it's bad news. Especially when the egg hosts the Red Death virus named Thrax (my favorite character), voiced superbly by a evilly suave and utterly unrecognizable Laurence Fishburne. Thrax wants to kill Frank in record time (48 hours) by damaging his hypothermis gland and heating Frank up like "A sidewalk on a summer day..." Thrax snickers.
To help Osmosis fight Thrax, enter the by-the-book and not particularly bright cherry-flavored cold pill Drix (David Hyde Peirce)who wants to prove his worth by curing Frank.
The In-Jokes, such as taking you're girlfriend down to the kidneys to see the stones and an armpit being a sauna for gangsters make it funny. The live-action parts are disgusting with vomit jokes and require fast forwarding. And the action scenes near the end, involving car chases and fistfights, are just cool. It's a little violent within the body; Thrax's sicle-like index finger is used for slicing apart those unfortunate cells that stand in his way and for setting fire to his surroundings. Lots of pyromania. Rock, Peirce, and especially Fishburne lend excellent voice talent to this movie. But not for the squeamish.
Most Recent Customer Reviews
A decent popcorn movie. A unique concept...But very predictable once you grasp what's going on. I wouldn't pay to watch it again.Published 18 days ago by John Sentell
Can't go wrong with Osmosis Jones! That pimple busting part was the best! LolPublished 1 month ago by joe h.
Awesome movie, my 6 yr old grandson loved it, wanted to rent over & over so we just bought itPublished 1 month ago by Amazon Customer
Great movie, amazing animation, but beware, there's a veeery gross vomiting scene somewhere in the middle. Felt ill for a while after that. Read morePublished 2 months ago by Jenelle Stewart
Great movie but poor quality picture. I have tried viewing the film on both my PC and t.v. but the picture is horrible. Read morePublished 2 months ago by Amazon Customer
Pretty good for what it is: a middle school science filler. It has a mediocre story, but fun characters, and some pretty good pseduo-science. Read morePublished 2 months ago by Amazon Customer
What Other Items Do Customers Buy After Viewing This Item?
Customers Also Watched on Amazon Video
Look for Similar Items by Category
- Movies & TV > Animation
- Movies & TV > Genre for Featured Categories
- Movies & TV > Movies
- Movies & TV > Science Fiction & Fantasy > Science Fiction > Animation
- Movies & TV > Studio Specials > Warner Home Video > Action & Adventure
- Movies & TV > Studio Specials > Warner Home Video > All Titles
- Movies & TV > Studio Specials > Warner Home Video > Comedy