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Showing 21-30 of 77 reviews(Verified Purchases). See all 135 reviews
on March 9, 2008
In "Overdosed America" Dr. John Abramson is mainly concerned with accuracy of information about prescription drugs and about medical devices and procedures in the United States. He shows how drug and device makers manipulate information to present their products favorably. Dr. Abramson leverages experience in public health policy, closely analyzing FDA fast-track approval of painkillers including Celebrex in 1998 and the now withdrawn Vioxx in 1999 (pages 23-38) and NIH revisions to cholesterol guidelines in 2001 (pages 129-148). For those cases, Dr. Abramson provides detailed readings of published studies, showing how drug benefits were promoted and hazards minimized.

Dr. Abramson's most egregious example concerns hazards of Vioxx. A key report about Vioxx appeared November 23, 2000, in the New England Journal of Medicine, then as now edited by Dr. Jeffrey Drazen. It included information about potential hazards. An apparently authoritative review article about Vioxx and Celebrex appeared August 9, 2001, in the same journal, with updated hazard information. The latter article said increased incidence of cardiovascular events associated with Vioxx "may reflect the play of chance." From data published in the latter article Dr. Abramson found that the cardiovascular hazard from Vioxx was statistically significant, unlikely to represent chance occurrences. However, FDA action on the information was delayed until September, 2004, when Merck withdrew Vioxx from the market because of its cardiovascular hazard. On December 8, 2005, the New England Journal of Medicine published a belated "Expression of Concern" saying authors of the November 23, 2000, article had omitted data which they then possessed, showing a greater incidence of cardiovascular events.

Writing before the 2005 disclosure, Dr. Abramson was incensed. Poring over information made available to the public by the FDA, he had already found that the FDA knew of a substantial cardiovascular hazard when Vioxx was approved. Members of the medical community had little access to this knowledge, unless willing to spend hours in background research as Dr. Abramson did, and the general public knew even less. Articles appearing in a major medical journal had promoted benefits of Vioxx and minimized hazards. Dr. Abramson reports pressure from his patients to prescribe Vioxx, inspired by advertising. He accuses "commercial medical research" of "rigging medical studies, misrepresenting...results" and "withholding...findings" (page xvii).

Dr. Abramson's proposed remedy is a new federal agency "to protect the public's interest in medical science" (page 250). It would set standards for "medical research," oversee development of "clinical guidelines," and initiate research "when important scientific evidence was lacking." While describing this new agency, Dr. Abramson does not say but appears to mean by "medical research" mainly "clinical trials" for prescription drugs and medical devices, not the basic research programs sponsored by the NIH and other agencies. The key power of the new agency over prescription drugs and medical devices would be certifications that clinical trials met its standards.

Dr. Abramson makes three more general recommendations to improve health care: a "rebalanced" "mix of physicians," financial rewards to health care providers for "improving the health" of their patients, and "adequate, stable funding" of the FDA and NIH, replacing [prescription drug and medical device] "industry money" (pages 255-256). Dr. Abramson does not provide guidance for making such changes. Instead he calls for "courageous leadership" from someone else, inviting "public hearings" investigating the Celebrex and Vioxx approval processes and investigating "commercial bias in the 2001 update to the cholesterol guidelines."

Despite the intensity of his investigations, Dr. Abramson does not seem to have spent comparable energy on his proposed remedies. Unlike many economists, he seems much impressed with the effectiveness of the Federal Reserve Board and wants to model his proposed agency after it. His proposed new agency appears similar in spirit to "science court," long advocated under different names by Dr. Arthur Kantrowitz, the physicist who founded Avco-Everett Research Laboratory in 1955 and later became a professor at Dartmouth.

A key problem with "science court" was that it would duplicate functions of existing courts, with no clear way to resolve issues of jurisdiction. A key problem with Dr. Abramson's proposed agency is that it would duplicate functions already assigned to the FDA and the NIH, with no clear way to divide responsibilities. Since his core complaint is that those agencies failed, Dr. Abramson ought to have provided a history of how they came to fail and ought to have explored whether and how such failures could be remedied. Avoiding knowledge of failures invites their repetition, should Dr. Abramson's plan somehow be implemented.

Dr. Abramson left his medical practice in 2002 to teach primary care at Harvard Medical School, where he wrote his book. In a January, 2005, interview published by Managed Care, he disclosed frustration trying to teach students to examine evidence critically: "it creates dissonance for them." He explains that "medical students want to learn indications, doses and side effects, because that's what they'll be graded on." Dr. Abramson is himself a primary care physician who did learn how to extract knowledge from muddled evidence and unwarranted conclusions. While his book does not try to deal with a wide range of problems in United States medicine, it is clear and convincing in describing the issues it takes on.

"Overdosed America" can be most closely compared with "Powerful Medicines" by Dr. Jerry Avorn -- both books first published in late summer, 2004. Like Dr. Abramson, Dr. Avorn is an internist who teaches at Harvard Medical School. Unlike Dr. Abramson, Dr. Avorn has spent most of his career in academic medicine, currently heading a group of sixteen scientists and physicians called the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital in Boston. Dr. Avorn describes many of the same examples of problem drugs as Dr. Abramson -- including Vioxx, statins and hormone replacement therapy -- but his attitude is different. Where Dr. Abramson is sometimes incensed, Dr. Avorn is philosophical. Faced with probabilities of drug hazards, Dr. Abramson estimates the number of his patients who may suffer. Dr. Avorn says about such issues, "I don't intuit them well" (page 167). Instead, he says he has "developed a passable prosthetic sense of such things."

A policy professional will probably find Dr. Avorn's explorations of prescription drug issues interesting and helpful. Most potential readers will find more insight and motivation in Dr. Abramson's book. It is a long read, travelling through territories likely to be unfamiliar. At the end of the journey, a persistent reader will understand a major problem affecting medical care in the United States and will have some sense of what needs to be done to deal with and correct it.
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on December 9, 2011
this book is an absalute must read for everyone. There is info on drugs fitness. hospital test's are those test's really needed.
overdosed Amertica will really open your eyes. you will finally realize that you have to take ultimate control of your health.
exercise is so important to your health. This doc recomends a exercise bike for fitness. If you are way out of shape with health issues, like bad knees
poor mobility. Then a recumbent bike is your ticket. I have one now thanks to this doc. work out on it three times a week. I feel I am making progress already. I am very happy with this book YOU WON'T REGRET BUYING this life saver. There are no magic pills for everything. Learn what you need to take , what to avoid taking. Good Luck with your health!!!!!!!!!!!!!!!!!!!
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on August 28, 2011
This is one of the best books I've ever read on healthcare (and I've read quite a few). Abramson absolutely nails what's wrong with healthcare in this country. Ever wonder why you can't turn on the television without being blitzed by arthritis ads? Or why the United has the most expensive health care in the world, but poor health outcomes compared to other countries? Do the expensive heroic surgeries and interventions for cancer and cardiac events really save lives? You will be amazed by what you learn in this book. And Abramson doesn't dumb down the science--he leads you carefully through the analysis that guides his conclusions, so you can see for yourself how pharma companies manipulate the numbers to bolster use of dubious new products. Talk about "lying with statistics."

After you read Overdosed Americans, I recommend reading Overdiagnosed by Welch. The authors of Overdiagnosed come to similar conclusions as Dr. Abramson, but they focus on a few of the big oversold conditions (osteoporosis, high blood pressure) and concentrate more on what you need to know as a consumer.
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on October 15, 2008
I am glad I ordered this book even though I already knew the FDA is not really the friend of consumers.

Drug companies are much more interested in the greenback than the health of consumers. This book goes into specifics on how drug trials are slanted to ignore almost all downsides to new drugs and how some so-called drug trials are really marketing ploys in disguise.

Check it out yourself. You will think twice next time a prescription is offered to you. Ask your doctor how long you will need to take it and about possible side effects. Get the information necessary to be an informed consumer. And be willing to research EVERY prescription drug that might be ordered.

Standard medical practice requires a physician to order a prescription if you have certain symptoms such as high cholesterol. What they don't seem to realize is that the possible side effects of the statin drugs are far worse than the touted damage of cholesterol in the 200-250 range.

There are also physicians that say you are in trouble if your cholesterol is LESS than 200.

I suspect the falls many elderly people experience are increased in number by polypharmacy (multiple prescriptions).

Do your own research, too. Aren't you worth the time and effort to do so?
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on September 5, 2012
"Overdosed America" contains weighty material, but will be understandable for the typical person. A medical education is not necessary for the reader to understand how the pharmaceutical industry slants their advertising and even the claims they make to your doctor when their rep "informs" the doctor about new medical developments and leaves off the free samples. We, as medical consumers, have more to worry about than we are told, and very often can expect much less from the medication than we believe. There are things we CAN do to improve our own health, but most often taking medicine is much less significant than the other measures we can take. The book details many specific meds and explains the misleading aspects of the research and claims -- also, sadly, how much many doctors do not know about the meds they prescribe. Good read.
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on September 3, 2014
This is a wake up call for America which may be lost on the "older generation" but affords our youth an opportunity to approach and take charge of their own health concerns. Medication isn't the answer! Good nutrition, adequate exercise and a mindful view of life produces a wonderful quality of life for everyone.
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on February 27, 2014
This book should be required reading for every intelligent person in this country. It details the extent to which false and misleading information has become the basis for current recommendations and guidelines, and how even the most trusted journals and institutions have become to a large extent influenced by the billion dollar drug industry. This is not an anti-establishment propaganda-type book, but is carefully referenced with a measured and highly credible tone.
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TOP 1000 REVIEWERon November 20, 2004
In the news this morning (November 20, 2004): The Associated Press reports that shares in pharmaceutical giants AstraZeneca PLC and GlaxoSmithKline PLC dropped after safety concerns over the anti-cholesterol drug, Crestor, and asthma drug, Serevent, were raised. For those who have read Dr. Abramson's book, Overdosed in America, safety concerns with Crestor will come as no surprise.

Dr. Abramson has done a more than credible job of researching the current state of medical care in the United States (taking three years away from his private practice to do so). Examining the links between emphasis on lowering cholesterol and drug company profits is just one area of current American medical care he tackles.

There are those who will argue that his common-sense approach to reducing health care costs while, at the same time, increasing American health, is too simple to be worthwhile. However, Dr. Abramson's recommendations are based on solid research findings. Sometimes, answers can be simple.

Overdosed America is an important book backed up by Dr. Abramson's painstaking research. Read it to save your wealth. Read it to save your health.

December Update:

I am astonished to see such highly negative reviews of Overdosed America. Are these the same folk who would never buy an automobile or vacuum without checking Consumers' ratings?

Surely, they have failed to read the book carefully or they could not suggest that much valuable research will be lost if we become actively involved in our own medicine and related pharmaceuticals instead of passive consumers of whatever latest pill that's being pushed.

Surely, they have failed to read carefully if they believe that the studies "proving" the safety of pharmaceutical are always fully and accurately reported.

My only beef with Dr. Abramson is that he is, in my opinion, far too lenient on doctors. While I realize that they are already overworked, I think that prescribing pharmaceuticals about which they know only what is given them by drug company representatives is reprehensible. We all have our part to play to keep medical costs and medical errors under control. To my mind the responsbility falls on doctors just as much as consumers.

Nonetheless, this book is far more than a sensationalism of the problems with current pharmaceuticals. The information it contains could save a life - your life or someone you love!

Phyllis Staff, Ph.D.
author, "How to Find Great Senior Housing"
and
"128 Ways to Prevent Alzheimer's and Other Dementias"

P.S. Added October 18, 2006: Events of the last two years have only buttressed the premise of Abramson's book. This is a "must-read" for anyone concerned about health and well-being. Don't miss it!
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on March 26, 2014
Overdosed America: The Broken Promise of American Medicine is an excellent book written by a doctor, who is telling it like it is . It was very well written. It is scary to think the number of drugs that Americans are using. It is a book that most people should read. People need to become totally aware of what is happening in this country. They need to do more reading, because there is so much more to read and learn, This book has a lot to offer.
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on August 10, 2015
This book is fantastic! So well written and easy to understand even for us patients. So proud to see him speak the truth and share it!! I recommend this book for anyone who needs an 'educational adjustment'. Thank you Dr. Abramson
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