- Hardcover: 376 pages
- Publisher: Wiley; 1 edition (February 15, 2011)
- Language: English
- ISBN-10: 047057755X
- ISBN-13: 978-0470577554
- Product Dimensions: 8.4 x 1 x 11 inches
- Shipping Weight: 2.5 pounds (View shipping rates and policies)
- Average Customer Review: 1 customer review
- Amazon Best Sellers Rank: #4,060,689 in Books (See Top 100 in Books)
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Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up 1st Edition
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The Amazon Book Review
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"This book presents detailed discussions of the published process chemistry of the ten top-selling small molecule drugs in the US in 2007, information which is usually carefully protected by the current and future manufacturers." (TMCnet.com, 17 March 2011)
"[This] book contains a wealth of information, taken from the patent literature and from [the author's]decades of experience in process chemistry. Through discussions on route selection [he]introduces practical aspects of route design, including selecting non-toxic, stable and inexpensive starting materials, reactions that minimize impurity contents with optimized yields, and ease of purification. [Dr. Harrington] lays out the various approaches to successful molecules, including biocatalysis, and sorts out which routes are acceptable, creative, likely to be the manufacturing route, or merely holding space.... [This] book will be extremely valuable for the process chemist who wants to delve deeply into details critical for process optimization, and for the student new to chemical process R&D in the pharmaceutical and CRO / CMO industries."
—Neal G. Anderson, Anderson's Process Solutions LLC and author of Practical Process Research & Development
Top customer reviews
Throughout his book Harrington discusses many practical points of process introduction. For instance: the preference of charging liquids over solids; reactor volume throughput typically preferred on scale; possible incompatibility of HCl salts with 316 SS reactors, and how drying solids under reduced pressure can break an azeotrope and extend drying time. He poses questions, some that an earnest student would follow and answer. Other questions might only be answered only by a researcher who worked on the particular compounds, but who did not necessarily describe all the details uncovered or developed.
Harrington's perspective is pragmatic: "Good science does not always make good business sense." He invested a great deal of energy in describing reactions and workups; such extremely detailed information can be mined for nuggets that the reader could potentially apply in their own work. For instance, many readers may be surprised that Ca or Na salts can be extracted into EtOAc.
Harrington's book will be extremely valuable for the process chemist who wants to delve deeply into details critical for route selection and process optimization, and for the student new to chemical process R&D in the pharmaceutical and CRO / CMO industries.