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Principles of Population Genetics 4th Edition

by Daniel L. Hartl (Author), Andrew G. Clark (Author)

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Principles of Population Genetics, Fourth Edition, is a thoroughly updated introduction to the field that is at last ascending to its rightful position of centrality to evolutionary genomics and human genetics. Rapid and inexpensive genotyping and sequencing have produced a profusion of data on genetic variation, along with a pressing need to inform students from many fields about the models that describe the underlying processes that give rise to observed patterns of genetic variation. This book provides a balanced presentation of theory and observation for students at the undergraduate and graduate levels as well as newcomers from fields like human genetics. The logical development of the models of population genetics encourages a deeper understanding of the principles, and the text has been rewritten with the goal to optimize its use as a teaching aid. It introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Integrated throughout the book are descriptions of molecular methods used to study variation in natural populations, as well as explanations of the relevant estimation theory using actual data.

Chapter 1 presents the fundamental observations and means for quantifying amounts and structure of genetic variation in natural populations. Chapter 2 gives a detailed examination of the implications of random mating for one locus and multiple loci and establishes the basic principles for thinking about mathematical models of variation. Chapter 3 presents the classic Wright-Fisher model as well as the coalescent approaches to random genetic drift. Chapter 4 adds mutation to models of drift and lays down the foundations for the neutral theory of molecular evolution. Natural selection in its many guises gets a thorough coverage in Chapter 5. Chapter 6 examines population subdivision and its consequences for the distribution of genetic variation among subpopulations, including the hierarchical F statistics used in estimating these effects. Molecular population genetics, including applications of coalescent theory, is the subject of Chapter 7. Evolutionary quantitative genetics is covered in Chapter 8, including an up-to-date treatment of the use of molecular markers for mapping and assisting in selection of quantitative characters. Chapter 9 is a new addition and covers the exciting field of population genomics, or the analysis of population genetic principles at a genome-wide scale. Finally, because of the explosion in genome-wide polymorphism data in humans and the realization that many problems in empirical population genetics need to be tuned to special, non-equilibrium circumstances of human populations, the authors devote Chapter 10 to human population genetics.

Applications of principles discussed in the text are illustrated with numerous examples of worked problems, using actual data. Many vital Web links are scattered throughout the text to connect the material to up-to-the-minute progress in this exciting field. Each chapter ends with a complete summary and offers several problems for solution, to reinforce and further develop the concepts.

ISBN-10

0878933085
ISBN-13

978-0878933082
Edition

4th
Publisher

Sinauer Associates is an imprint of Oxford University Press
Publication date

December 31, 2006
Language

English
Dimensions

9.4 x 1.5 x 7 inches
Print length

672 pages
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Editorial Reviews

Review

"It is a pleasure to read this new edition of a classical textbook on population genetics. It shows very convincingly how population genetics has been revamped in the past twenty years by the introduction of new statistical and computational methods (in particular, coalescent theory), and the advent of genomic data, as well as how these developments changed a formerly rather arcane science and moved it toward the center of modern biology. In summary, the essence of population genetics is nicely condensed in this book. The presentation is wonderfully balanced between theory and observation, as well as classical and recent data sets and analysis tools."
--Wolfgang Stephan, The Quarterly Review of Biology

Book Description

Provides a balanced presentation of theory and observation

Product details

Publisher ‏ : ‎ Sinauer Associates is an imprint of Oxford University Press; 4th edition (December 31, 2006)
Language ‏ : ‎ English
Hardcover ‏ : ‎ 672 pages
ISBN-10 ‏ : ‎ 0878933085
ISBN-13 ‏ : ‎ 978-0878933082
Item Weight ‏ : ‎ 3.3 pounds
Dimensions ‏ : ‎ 9.4 x 1.5 x 7 inches

Best Sellers Rank: #1,419,537 in Books (See Top 100 in Books)
- #1,067 in Genetics (Books)
- #6,007 in Biology (Books)
- #54,049 in Unknown

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4.6 out of 5

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Silvainilla

Great reference for Pop genetics

Reviewed in the United States on March 10, 2022

Verified Purchase

My professor of pop. Genetics recommended thus book as the main reference for the class, and he wasn’t wrong, it’s truly so helpful. They also share a good section of problems at the end of each section, and you have solutions for some. It is a known reference to have, if you are in this field.

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Anonymous

An excellent resource

Reviewed in the United States on January 11, 2018

Verified Purchase

This one is a must-have if you're interested in population genetics. I noticed this title on a bookshelf in my mentor's office and just went ahead and purchased it for myself without even looking at it. I am so glad that I got this book! I confess that some of the math is currently way over my head, but perhaps I will "grow into" this book (I'm a graduate student, working on my Master's now). I hope to use this as a reference in the future. I used this book as a supplement to another book for a required Evolution course that had a quantitative emphasis, and it really helped me to understand the material.

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JimBob

The book is as advertised - as good as new

Reviewed in the United States on December 17, 2016

Verified Purchase

It was delivered earlier than expected. The book is as advertised - as good as new.

Reviewed in the United States on July 23, 2017

Verified Purchase

Wound up not needing to use this one, but skimmed the material anyway. A pretty good introductory book for population genetics- college level studies.

Reviewed in the United States on August 26, 2016

Excellent

Reviewed in the United States on January 23, 2016

GOOD BOOK

Most intuitive approach to popgen

Reviewed in the United States on November 14, 2012

I've looked at a few population genetics books and this is by far the most explanatory and up-to-date with the field of population genetics that I've seen (it even includes some post-human genome sequencing era related material). This book provides in-text references to original publications, providing you with a means to start exploring the topics in more detail (very handy in my own work as a young bioinformaticist). I highly recommend this book for those serious about learning population genetics.

6 people found this helpful

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EDU

Principles of Population Genetics

Reviewed in the United States on January 28, 2007

Verified Purchase

It is a classical text, but it lack of a chapter on Conservation Genetics

6 people found this helpful

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Vinay Sagar

A very good book as a starter to population genetics

Reviewed in India on September 10, 2019

Verified Purchase

I had read the book earlier and loved it. So, I ordered my own copy as I feel this is one book to have if you're working in the field of population genetics.

One person found this helpful

Kausik chakraborty

Five Stars

Reviewed in India on April 15, 2017

Verified Purchase

Good packaging and delivery! The book is amazing, but it is technical so not discussing it here

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