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Proferrin ES Heme Iron Polypeptide Dietary Supplement Tablets, Blue/Green, 90 Count, Basic

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1,039 ratings

| 29 answered questions

Amazon's Choice in Iron Mineral Supplements by Proferrin ES

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Size: 90 Count (Pack of 1)

90 Count (Pack of 1)

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Brand	Proferrin ES
Item Form	Tablet
Primary Supplement Type	Iron
Unit Count	90 Count
Flavor	Unflavored

About this item

Oral Heme Iron
10.5 mg of Iron as Heme Iron Polypeptide
Naturally occurring iron source
Recommended Use: Take one tablet up to three times daily, with or without food
Made in the USA by Colorado Biolabs, Inc
During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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From the manufacturer

Proferrin ES is an iron supplement with Heme Iron Polypeptide, a natural form of iron that effectively provides benefits you simply can’t find with other iron sources.

Compared to traditional non-heme iron supplements, Proferrin ES offers:

10-23 times greater absorption **
- One Proferrin ES tablet provides as much absorbable iron as over 12 ounces of steak
Proven to have less side effects ***
- Less than 2% instance of GI side effects in multi-center clinical study(common among non-heme iron supplements)****
Can be taken with or without food
- Not affected by coffee or calcium
- Does NOT have to be taken with Vitamin C
Made in the USA
- Unlike other iron sources, Proferrin Heme Iron Polypeptide is manufacturer at our US facility
10.5 milligrams of iron in every tablet
- No need to take several tablets (like beef spleen products) or wonder how much iron is in Proferrin. We test every batch!


Absorption Heme iron simply provides significantly more absorbable iron compared to non-heme iron. With Proferrin, the body can absorb 10-24 times more absorption as compared to a typical (non-heme) iron supplement.**	Not effected by coffee, calcium, or PPI's A common issue with non-heme iron supplements, Proferrin is NOT effected by coffee, calcium, PPI's, and can be taken with or without food!*	Easy on your gut With non-heme iron supplements, "free iron" can cause GI side effects. With Proferrin, higher absorption leads to less "free iron" in the gut as compared to non-heme iron supplements.*

* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

** Nam, Tae-Sik & Shim, Ji & Kim, Byung-Ju & Rah, Young & kwang hyun, Park & Kim, Seon-Young & Mun, Eun-Gyeng & Jeong, Young-Ju & Han, Myung-Kwan & Cha, Youn-Soo & Chae, Soo-Wan & Im, Mie-Jae & Kim, Uh-Hyun. (2006). "Clinical Study on the Iron Absorption from Heme-Iron Polypeptide and Nonheme-Iron*." Nutritional Sciences The Korean Nutrition Society. 9. 295-300.

*** Ndegwa, Sarah, and Raymond Banks. (2007). “Heme Iron Polypeptide (Proferrin) versus Oral and Injectable Iron Products for the Treatment of Anemia.”

****Abdelazim IA, Abu-Faza M, Elbiaa AA, Othman HS, Alsharif DA, Elsawah WF. Heme iron polypeptide (proferrin-ES) versus iron saccharate complex (ferrosac) for treatment of iron deficiency anemia during pregnancy. Acta Med Int 2017;4:56-61

Product Description

Proferrin ES is a Dietary Iron Supplement that is Made in the USA by Colorado Biolabs, Inc. Each Tablet contains 10.5 mg of Iron as Proferrin Heme Iron Polypeptide. Heme is a natural form of iron derived from USDA edible red blood cells and is intended for individuals seeking to maintain normal iron levels. Recommended Use: Take one tablet up to three times daily, with or without food. Proferrin ES should be stored at room temperature. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Product details

Product Dimensions ‏ : ‎ 4.25 x 2 x 4.25 inches; 3.68 Ounces
Item model number ‏ : ‎ GHSTM
Date First Available ‏ : ‎ August 15, 2014
Manufacturer ‏ : ‎ Proferrin ES
ASIN ‏ : ‎ B00MJPVZC6
Country of Origin ‏ : ‎ USA
Domestic Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
International Shipping: This item can be shipped to select countries outside of the U.S. Learn More

Best Sellers Rank: #18,715 in Health & Household (See Top 100 in Health & Household)
- #61 in Iron Mineral Supplements
- #2,357 in Sales & Deals

Customer Reviews:
1,039 ratings

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Customer Rating	(1039)	(146)	(60)	(295)	(19)
Price	$57.22	$63.50	$33.95	$34.99	$16.95
Shipping	FREE Shipping. Details	FREE Shipping. Details	FREE Shipping. Details	FREE Shipping. Details	FREE Shipping on orders over $25.00 shipped by Amazon or get Fast, Free Shipping with Amazon Prime
Sold By	Amazon.com	Amazon.com	Health or High Water	PharmarisCanada	Pharmvista
Allergen Information	Gluten Free	Gluten Free	—	—	Dairy Free
Brand Name	Proferrin ES	Proferrin	Deep Blue Health	PHARMARIS HEME BOOST HEME IRON	Pharmvista
Diet Type	Gluten Free	Gluten Free	Plant Based	Halal	Gluten Free
Material Type Free	Gluten Free	Wheat Free	preservatives free	—	Gluten Free
Primary Supplement Type	Iron	Iron	Iron	Iron	Folic Acid,Vitamin C,Iron
Product Benefits	Iron Support	Iron Support	—	Immune Support	Iron Deficiency Management

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Important information

Safety Information

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately. CAUTION: Individuals with disorders leading to high iron levels such as hemochromatosis should not ingest iron supplements.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Other Ingredients: Microcrystalline cellulose, croscarmellose sodium, silicon dioxide, calcium stearate, povidone, and green coating [polyvinyl alcohol, polyethylene glycol, talc, FD&C Yellow #5(aluminum lake), FD&C Blue #2(aluminum lake), and titanium dioxide]

Directions

RECOMMENDED USE: Take one tablet up to three times daily, with food

Legal Disclaimer

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Customer reviews

4.6 out of 5

1,039 global ratings

5 star		81%
4 star		11%
3 star		4%
2 star		2%
1 star		3%

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Top reviews from the United States

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Kilji Gutierrez

I don’t think I will ever have to get an iron infusion again and I’m not being dramatic

Reviewed in the United States 🇺🇸 on December 14, 2022

Size: 90 Count (Pack of 1)Verified Purchase

I’ve always been low on iron since a teenager and I couldn’t ever find a supplement that would help me so I had to start getting infusions and with proferrin when I started to feel low in iron and I didn’t not want to go and get another infusion, started taking proferrin, and within three weeks. I’ve felt amazing This is no joke. This is the real deal.

6 people found this helpful

Helpful

Leckerli

Increases ferritin. Zero side effects. Take 3 daily, cut pills to facilitate disintegration.

Reviewed in the United States 🇺🇸 on September 21, 2017

Size: 30 Count (Pack of 1)Verified Purchase

23 days of proferrin, and my ferritin has gone from 18 to 32. No side effects to speak of, except that I can run with energy again. It is such a gift to feel my strength again, like youth. I'm continuing with this.

I was taking iron bis-glycinate, but while effective when taken on an empty stomach, I felt like I had swallowed a balloon. When I took iron bis-glycinate with meals (away from calcium), it was not effective after 4 months of use.

I take proferrin with meat stock first thing in the morning; apparently it absorbs better in the presence of amino acids: "free amino acids as cysteine, lysine and histidine enhanced heme and ionic Fe absorption in experimental models". Also iron absorption is apparently not sensitive to calcium in doses of less than 800 mg at a time. "Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams". Where other forms of iron are inhibited by phytates and polyphenols, heme iron is not. Lastly, I understand (hopefully correctly) that heme iron may cause less oxidative stress than other forms. I hope that as a result, it lowers the risk of Alzheimer's disease associated with iron supplementation.

Update: I was taking 1 pill per day at the time of this review. Since then my ferritin levels dropped to 20, so I began taking 2 per day. Fortunately I did this without any gastrointestinal upset, but unfortunately, 2/day only brought my ferritin up to 21 (I got this blood test result back today). Iron repletion is obviously extraordinarily complex. I'm baffled by it.

Update July 2018:
My ferritin dropped to 20, then to 17, 13, and finally to 10 while taking approximately 7 proferrin per week. During that time I tried alternating schedules, taking it with broth, lactoferrin, pepsin. Nothing worked. Once my ferritin had dropped to 10, I decided to take 30 mg per day, which is apparently the max you can take without causing expression of Hepcidin (prevents the uptake of iron). Also, I had been inspecting my stool (I know, gross...) and found pockets of dry black powder from undissolved proferrin pills. These pills look like black charcoal on the inside, which is probably why the coat is colored (green). Obviously absorption won't happen if they haven't dissolved.
I started taking 3 pills (30 mgs) each morning, all at once, on an empty stomach, away from calcium. Most importantly, I cut each pill in half before taking, which seemed to help disintegration because I found no more black powder in stools. As a result, my ferritin climbed back up to 17 after 1 month of this routine. I'll continue checking ferritin levels each month until it has reached a steady state. Hopefully no more downturns.

Update November 2018:
My monthly ferritin levels have continued to rise on the schedule of three pills per day, cut, on an empty stomach, and away from calcium. Here are my ferritin results (ng/ml): August (16), September (21), October (25), and November (40). Awesome. Feeling so much better.

56 people found this helpful

Helpful

danicat

MIRACULOUS!!! In 2 months, ferritin went from 14 to 47, iron from 30 to 80, hemoglobin from 12.1 to 13.5!

Reviewed in the United States 🇺🇸 on September 7, 2016

Size: 30 Count (Pack of 1)Verified Purchase

My hemoglobin levels have been in the "normal" range for quite some time, but my serum ferritin levels have been low for many years. I just didn't know it was such a serious issue until I was diagnosed with PLMD or PLMS (Periodic Limb Movement Disorder) in the summer of 2014. My sleep doctor recommended that my primary care physician check my serum ferritin level and that it should be at least 50-60 to mitigate the effects of having PLMD (or restless leg). My ferritin level came back--9! This is considered "normal" on the bloodwork, but not in journal articles. They frequently mention low ferritin as a possible cause of many issues like depression, fatigue, restless leg, thyroid problems, etc.

I ate a bunch of meat that summer into fall--like every day for four months--and my level increased to 12. Then I tried other iron supplements: iron bisglycinate, dessicated beef liver pills, Floradix, Hema-plex, Ferrasorb, etc., for almost a year. The ferritin increased to 15. I felt like I was getting nowhere.

Then in the middle of the night during one of my awake periods earlier this year (2016), I was researching PLMD and restless leg journal studies desperately searching for an answer. I came across a journal article that said that heme iron worked a lot better than non-heme iron and patient ferritin levels increased dramatically in a short period of time. I googled heme-iron supplements in the US and found Proferrin. I thought it couldn't hurt because my iron had been tested mid-February and had gone back down to 14. I felt like I had to do something, but it's kind of expensive, so I started with this 30 pill bottle.

I bought it on March 12. It arrived on the 14th. I started taking 1-2 pills a day until I had my blood checked again on May 19th. My serum ferritin level had increased from 14 to 47!!!!!!!! My hemoglobin had increased from 12.1 to 13.5 and iron was up from 30 to 80! Very impressive results. Now, I order the bottle of 90! Proferrin ES Heme Iron Polypeptide Dietary Supplement Tablets, Blue/Green, 90 Count . I had surgery in June and lost a lot of blood, so I am taking it again...this time 2-3 pills per day. I also take iron cofactors--B12 (hydroxocobalamin) and methylfolate (L-5-MTHF). I don't know if those help, but I've taken them before with other iron supplements and never had my iron levels get up so high! So I would highly recommend this iron supplement...especially if you're a menstruating woman who's ferritin level is below 50!

124 people found this helpful

Helpful

Blackthorne

Without Proferrin, I have to have Iron Infusions.

Reviewed in the United States 🇺🇸 on October 15, 2021

Size: 90 Count (Pack of 1)Verified Purchase

My body doesn't absorb iron the way other people do, and I have had anemia severe enough to need multiple iron infusions from a hematologist. Proferrin isn't cheap, by any means, but they have helped me stave off the need for iron infusions for over five years. This helps to counteract my intestinal malabsorption that prevents me from absorbing iron from food or other supplements the way most people do. This isn't just a 'vitamin boost' for me - it's a required part of my daily life to avoid dying.

What's helpful to me is that they do not interfere with the absorption of calcium like some other 'iron' supplements do, so I am able to take them throughout the day. Because of my condition, I require more than a normal person would, and I have bloodwork drawn several times a year to confirm that I am not overdosing on it.

8 people found this helpful

Helpful

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