Digital List Price: $26.99
Kindle Price: $13.19

Save $13.81 (51%)

These promotions will be applied to this item:

Some promotions may be combined; others are not eligible to be combined with other offers. For details, please see the Terms & Conditions associated with these promotions.

Deliver to your Kindle or other device

Deliver to your Kindle or other device

Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines by [Stockwell, Brent]
Kindle App Ad

Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines Kindle Edition

4.2 out of 5 stars 13 customer reviews

See all 4 formats and editions Hide other formats and editions
Price
New from Used from
Kindle
"Please retry"
$13.19

Length: 290 pages Enhanced Typesetting: Enabled Page Flip: Enabled

China
Engineering & Transportation Books
Discover books for all types of engineers, auto enthusiasts, and much more. Learn more
click to open popover

Enter your mobile number below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required.
Getting the download link through email is temporarily not available. Please check back later.

  • Apple
  • Android
  • Windows Phone
  • Android

To get the free app, enter your mobile phone number.


Editorial Reviews

From Publishers Weekly

Stockwell, professor of biology and chemistry at Columbia University, claims that the success drug companies have had developing specific chemicals to combat disease is likely coming to an end. According to Stockwell, the techniques scientists have used to fight disease up to now, binding drug molecules to proteins, may have reached its limit, as most proteins, it seems, cannot bind with drug molecules; they are "undruggable." But genes are "druggable." Stockwell is impressive in describing a new paradigm of pharmaceutical research that could open a host of new possibilities for currently untreatable diseases involving advances in genomics, molecular biology, and chemistry. By providing accessible explanations for the underlying biological and chemical principles that apply to the complex solutions he describes, Stockwell enables even the scientifically unsophisticated reader to gain a wider perspective on what future disease treatment might entail. He also brings to life the excitement of scientific research by highlighting classic experiments that have shaped our understanding of biological systems and profiling major players in the field. Illus. (June)

Review

The dearth of promising new treatments for many a serious disease remains a major challenge not just for the pharmaceutical industry but for all of society. In this exhaustively researched book, Brent R. Stockwell surveys the history of drug development and offers insightful suggestions for innovative new approaches. This is critical reading for the many involved in and concerned about this urgent issue.

(Robert Bazell, chief science correspondent, NBC News, and author of Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer)

This is a terrific book! Stockwell's writing is clear and engaging as he presents a thoughtful analysis of drug development that can be understood and appreciated by a diverse readership. Stockwell beautifully combines scientific history and personal anecdotes with clear explanations of the principles and practices of chemical biology to make a fascinating story of the past, present, and future of drug discovery. His book is informative, accurate, and a good read all put together.

(Geoffrey Cooper, Boston University, author of The Cell: A Molecular Approach and Oncogenes)

This is a truly wonderful book. Stockwell's writing will open the door to a universe that many readers may know little about. Drugs are born, biotech companies are created, scientists' careers are made and unmade, egos are raised and dashed. This book is so readable, it is an absolute page-turner. Yet it is also authoritative and scientifically sophisticated, managing to distill a complex, changing field into a beautifully written, well-crafted story.

(Siddhartha Mukherjee, Columbia University, author of The Emperor of All Maladies: A Biography of Cancer)

By providing accessible explanations for the underlying biological and chemical principles that apply to the complex solutions he describes, Stockwell enables even the scientifically unsophisticated reader to gain a wider perspective on what future disease treatment might entail.

(Publishers Weekly)

This very readable, even exciting work takes us through the medical breakthroughs of the past century.

(Globe and Mail)

This book deserves a readership, and there is certainly a need for it. As a drug companyresearcher, I have often wished that more people understood what the field was likeand how simultaneously fascinating and frustrating it can be.

(Derek B. Lowe Cell)

In this well-researched look into the complexities of making medicines, a chemical biologist gives a history of drug making and details innovative methods of drug discovery.

(Science News)

Despite our current political paralysis, government leaders should listen to Stockwell and be certain to advance our capacity to generate the drugs that our society and the world need.

(Harvard Magazine)

The book is well organized and includes many interesting, clever analogies to explain what can be complicated scientific problems.

(Choice)

An engaging and rewarding read...

(Donald C. Lo Journal of Clinical Investigation)

The reader is not only left with a satisfying overview of the proud history and future challenges of finding new medicines but also encouragement that Stockwell and his contemporaries are creatively committed to academic drug discovery.

(David Kroll Nature Chemistry)

Stockwell writes well―his prose is accessible to the educated reader, irrespective of his or her background. All of the personalities, errors and successes in contemporary drug discovery are presented. Stockwell enlivens their stories with anecdotes...

(Garrett A. FitzGerald Nature Medicine)

It is impossible to read this relatively short book...without being captured by the author's optimism about the future of drug development.

(Robert C. Young, M.D. Oncology Times)

Product Details

  • File Size: 2067 KB
  • Print Length: 290 pages
  • Page Numbers Source ISBN: 0231152124
  • Publisher: Columbia University Press (May 3, 2011)
  • Publication Date: May 3, 2011
  • Sold by: Amazon Digital Services LLC
  • Language: English
  • ASIN: B004ZGROYK
  • Text-to-Speech: Enabled
  • X-Ray:
  • Word Wise: Not Enabled
  • Lending: Not Enabled
  • Enhanced Typesetting: Enabled
  • Amazon Best Sellers Rank: #647,228 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
  •  Would you like to give feedback on images or tell us about a lower price?

Customer Reviews

Top Customer Reviews

By Jijnasu Forever VINE VOICE on May 16, 2011
Format: Hardcover
Drawing heavily from his research & academic backgrounds, Stockwell provides an informative account on drug discovery challenges and ongoing/potential approaches to address them. For a reader with medical background, this is an excellent read while a general reader will struggle with the details. (3.5*)

(Review adapted from my blog; free advance copy provided by the publisher)

At the very outset, Stockwell provides a succinct explanation of why drug discovery is far more challenging than what one may imagine - by focusing on the actual mechanics of "small drug molecules" and proteins involved in disease progression. (A reader can easily grasp this complexity when Stockwell highlights that only 2% of the proteins are now considered "druggable" and the generally risk-averse scientists typically tend to focus only on this minority due to commercial considerations.) The discussion on how drugs actually work may be of interest to the average reader. He then describes (with various examples) various drug discovery mechanisms and a history of cancer drugs. The role of luck in discoveries, of course, is well known...but through these discussions, one gets to appreciate not only the role of luck but also of perseverance and a systematic approach to design experiments. A subsequent chapter on the author's entrepreneurial experience provides some insights on the potential of studying combinations of approved drugs - but the narration is too focused on the company history, a reader is likely to be distracted.

The second part starts with an introduction to promising emerging techniques of drug discovery including structure-based designs, virtual screening, and fragment-based screening.
Read more ›
Comment 11 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Hardcover Verified Purchase
A great book. The author writes accessibly for the lay person and makes his tale interesting. My son is studying chemical engineering and is interested in biomedical topics, so we are enjoying reading about current happenings in the search for cures to difficult diseases. I appreciate the level of detail presented with the care taken to explain things as directly as possible. I have learned a lot. It is instructive and inspiring to learn of the author's early ambitions, lessons learned and his successes.
Comment 3 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Hardcover Verified Purchase
I bough the book so that I can introduce some examples in my lectures on insilico drug design. I enjoyed reading the book, and I have learned something. The professionals can enjoyed reading this book, but also the text should be understandable to the wide audience. I enjoyed that author has presented science and a little of real life stories behind the science.

I gave the book four stars, instead of 5 since the author primarily covered areas of his research experience, Most notably there is nothing on different computational methods that have been in development in the last 30 years, also computational methods are not included in discussing the future. I would not go into analysis why computational methods are missing, Simply this book is interesting, and it could have been great if some areas are not missing.

In conclusion, if there is a second edition, with few additions it could be a great text to read.Good luck in your lives folks, Cheers.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Hardcover Verified Purchase
Many books have been written about the development of new pharmaceuticals. It seems that a majority of these books focus on the scientist and business people involved in the industry and on the deadly diseases that these people are trying to cure. Not so with this book. This book focuses more on the discoveries and technology that make drug development possible.

Dr. Stockwell took the time in his book to explain the technology involved in discovering (or generating?) new drugs. You are going to finish this book knowing a lot more about biotechnology than when you started. That said, I can imagine that this book would be challenging to read to people outside the scientific community (I myself am a student).

I was a bit disappointed with the ending of the book. The author took great care to painstakingly explain several new important technologies. Then, at the end of the book, the author listed several other remaining technologies, all important, without describing them. I wished he would have spent more time explaining the future uses of siRNA and gene therapy. This is probably because these areas of research are outside the authors field of work, which I infer is Chemistry and not biology.

I recommend this text to anyone interested in the drug discovery field.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Hardcover Verified Purchase
I like the way Brent writes; my recommendation is to focus on less known stories in drug development. However, this is only a minor issue and I honestly recommend this book to professionals as well as the lay audience.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Format: Kindle Edition Verified Purchase
Brilliant! I bought this book because I wanted a better understanding of the drug development process. I thought it was going to be an interesting, but difficult, dense topic. To my amazement the author made very complex topics immensely understandable and pleasurable to learn about.

It instilled in me a sense of curiosity and wonderment in the drug development process that I never imagined before. Chemistry and biology stopped being dry, rote topics and became living breathing subjects that affect my everyday well-being.

Congratulations to the author for his mastery in explaining these challenging topics in easy to understand, accessible language. The book is a great accomplishment.
Comment Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse

Most Recent Customer Reviews

Set up an Amazon Giveaway

Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines
Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more about Amazon Giveaway
This item: Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines