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Receptors: Models for Binding, Trafficking, and Signaling

5.0 out of 5 stars 3 customer reviews
ISBN-13: 978-0195106633
ISBN-10: 0195106636
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Editorial Reviews

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"Bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modelling approach combines with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. . . . conceptually rich, timely, and useful." --Biology Digest


From the Back Cover

This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be especially useful.
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Product Details

  • Paperback: 376 pages
  • Publisher: Oxford University Press (January 11, 1996)
  • Language: English
  • ISBN-10: 0195106636
  • ISBN-13: 978-0195106633
  • Product Dimensions: 9.2 x 0.8 x 6.1 inches
  • Shipping Weight: 1.2 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (3 customer reviews)
  • Amazon Best Sellers Rank: #1,063,572 in Books (See Top 100 in Books)

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Format: Paperback
This book will surely be thought of as the first structured presentation of principles of modern systems biology. This book introduces the application of Chemical Engineering to biologists and molecular biology and pharmacology of receptors to Chemical Engineers. The top-down picture of coupled processes is not only new to biologists but introduces a whole new way to look at biological problems. Especially the chapter which has cell migration explained introduces one to multi-dimensional thinking: cell mechanics, biochemistry, kinetic modeling and molecular biology all in the same problem. This may seem mystical to many. Would probably be read more by Engineers than biologists, who are yet to take the leap in thought to multi-dimensional science.This book would be remembered after many years to be a pioneer in the new science of systems biology, although it was written much before the Human Genome Project. Systems thinking and Chemical Engineering has been much beneficial in solving some very important biomedical problems like Drug Delivery(Robert Langer), Tumor Biology(Rakesh Jain) and Tissue Engineering(Robert Langer et.al.). Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later.(Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August 2002.Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology.
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Format: Paperback Verified Purchase
Paid a ton of money to overnight this thing, have only ever read one page of it, and in fact I don't even really know what it's about, but it's perhaps the most important $86.37 that I've ever invested in my future. Thank you Dr. Lauffenburger.
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Format: Paperback
If you are thinking of purchasing a book on receptor-ligand kinetics, this is a wise choice. It is easy to follow and advanced enough for most graduate work in biochemical and biomedical engineering.
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