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Resistant Hardcover – May 20, 2014

4.2 out of 5 stars 273 customer reviews
Book 3 of 3 in the Dr. Lou Welcome Series

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Editorial Reviews

From Booklist

Dr. Lou Welcome is a fine Boston emergency-room physician who also happens to be a recovering addict. He is asked to cover for his boss at a medical conference in Atlanta, and takes his best friend, Cap, along. While out trail running, Cap severely injures his leg on a slippery slope; Lou manages to get him to the hospital, but that’s just the beginning of Cap’s problems. He picks up a new bug, nicknamed the Doomsday Germ by the press, while hospitalized. Turns out a right-wing domestic terrorist group created the germ, which they had planned on using to blackmail the U.S. government into shutting down all entitlement programs. But the flesh-eating bacteria grew out of control and became completely resistant to all known treatments, including the cure the terrorists thought they possessed. Even the Center for Disease Control is stumped. The FBI gets involved, and the race between the government and the terrorists to find a cure is on. Medical-thriller fans of all stripes will find much to enjoy here. Unfortunately, the author died in late 2013; whether there are any more books in the pipeline is anyone’s guess. --Stacy Alesi


“Plenty of chills and spills.” ―Kirkus on Political Suicide

“Fans won't be disappointed and Palmer can add another bestseller to his list.” ―Associated Press on Political Suicide

“A must-read for fans of political intrigue.” ―The Fort-Worth Star Telegram on Political Suicide

“When you open the pages of a Michael Palmer novel, you know you are in the hands of a pro.” ―The Huffington Post on Political Suicide

“Michael Palmer mixes politics, medical science and the military to create another suspenseful medical thriller.” ―Examiner.com on Political Suicide

“This is a definite keeper!” ―Suspense Magazine on Political Suicide

“Compelling and terrifying.” ―Kirkus on Oath of Office

“The twists fly in A Heartbeat Away and the results create a terrifying scenario…Palmer has a mastery of the medicinal science involved in such elaborate conspiracy, plus the intricacies of presidential succession.” ―Associated Press on A Heartbeat Away

“Prepare to burn some serious midnight oil.” ―The Boston Herald on The Last Surgeon

“Endlessly entertaining. The roller-coaster ride of a plot builds to an undeniably shocking conclusion.” ―Publishers Weekly on The First Patient

“The novel is not merely a thriller but also an exploration of its central character's unique gifts and her determination to communicate with her comatose father despite overwhelming odds. Another winner from a consistently fine writer.” ―Booklist on The Second Opinion


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Product Details

  • Hardcover: 400 pages
  • Publisher: St. Martin's Press; First Edition edition (May 20, 2014)
  • Language: English
  • ISBN-10: 1250030927
  • ISBN-13: 978-1250030924
  • Product Dimensions: 6.4 x 1.3 x 9.5 inches
  • Shipping Weight: 1.3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (273 customer reviews)
  • Amazon Best Sellers Rank: #584,197 in Books (See Top 100 in Books)

Customer Reviews

Top Customer Reviews

By Gail Rodgers VINE VOICE on April 5, 2014
Format: Hardcover Vine Customer Review of Free Product ( What's this? )
It was gut-wrenching for me to read this book of one of my favorite medical-thriller authors. While I've had other favorites that announced they would be retiring, none have ever died in the midst of a brilliant writing career. I was fortunate enough to read and review one of his other books that he sent me and also had several email exchanges, so in many ways he felt like a personal friend. Michael died in October 2013 when he had apparently finished most of this book, Resistant, and his family took it the rest of the way to complete production. It is hard to think that I will never get another new book of his to read. I tried to read this one slow to make the moment last, but as with all his books I got caught up in the story and the pace of the book and finished it way too soon.

This book was about a strain of bacteria that was resistant (hence the title) to all normal forms of antibiotics and had been released by a domestic terrorist group as a way to motivate the government to cancel out all entitlement programs such as Social Security, Medicare, Medicaid, welfare, food stamps, etc. Of course many in the group lived in luxury so they felt a different sort of entitlement. Dr. Lou Welcome, a recurring character in Michael's last few books, becomes heavily involved for personal reasons in trying find a cure for this bacteria that in Lou's words “turned the inside of a body into liquid”, and not nice liquid. We are introduced to a new character that Lou became great friends with named Humphrey Miller, a brilliant man with the worst kind of cerebral palsy. I could see him in further recurring roles in other books and the same with Lou's friend Cap whose life was changed forever in this last book.
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Format: Hardcover Vine Customer Review of Free Product ( What's this? )
Michael Palmer wrote about what he knew (he died of a heart attack in November 2013). Palmer was an emergency room physician who battled and controlled addiction problems.

In "Resistant," Dr. Lou Welcome was an emergency room physician who became a director of an addiction program for physicians. Dr. Welcome suffered from drug and alcohol addiction, which he controlled through a sponsor and a ten-step program.

The addiction program became an integral part of this mystery/thriller plot. Dr. Welcome's sponsor has a running accident, resulting in a compound fracture that becomes infected with deadly, hospital-acquired, flesh-eating bacteria. The bacterium is drug-resistant. The remainder of the story concerns a type of germ warfare by a group (cult) of terrorists and the race by researchers to find a means of conquering the deadly bacteria.

Palmer took bits of reality and interwove them to create a gripping medical-mystery thriller. Drug-resistant, virulent bacteria do exist, although cases of necrotizing fasciitis are extremely rare. The bacteria are not really flesh-eating, but their result is the same. They release toxins that cause the destruction of skin and muscle. Treatment is debridement (removal of the infected tissue), amputation and hyperbaric oxygen.

"Resistant" echos the story of Georgia student Aimee Copeland. In 2012, she suffered a zip line accident causing a gash in her leg. Antibiotic-resistant, "flesh-eating" entered the wound. Treatment resulted in the lost of one leg, a foot, and both hands.

Palmer writes great medical mystery thrillers, and I have read all of them. Sure, there are good guys, bad guys, conspiracy and kind, brave heros with flaws. Call it formulaic, but it works for me. I found "resistant" to be a real page-turner and a satisfying read.
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Format: Hardcover Vine Customer Review of Free Product ( What's this? )
“Resistant” is the third novel that I have read featuring Doctor Lou Welcome by Michael Palmer. Like “Oath of Office” and “Political Suicide,” this was an entertaining 387-page, quick and easy read that was really hard to put down.

These books can be read in any order; however, I would recommend reading them in chronological order to maximize the development of the flawed character of the good doctor. The father of 14-year old fourteen-year-old daughter, Emily and ex-husband of remarried, Renee, Doctor Welcome is a recovering alcoholic and drug abuser. Lou has made major headway to get back on the straight and narrow regaining the friendship and mutual respect with Renee as a result of the help of his sponsor and now best friend, Hank “Cap” Duncan a former prize fighter and owner of the Stick and Move boxing gym.

Previously stripped of his license to practice medicine, board certified in both internal and emergency medicine, Welcome is has successfully regained his medical license and is helping others recover from their addictions and behavioral problems while working at the Physician Wellness Office (PWO) in Washington, D.C., as well as the ER of Eisenhower Memorial in that city.

After “Cap” suffers a broken leg complicated by the contraction of a deadly nosocomial inflection, Lou embarks on a mission to find a cure and in the process finds himself a target of a secretive extreme right wing organization of strategically placed powerful individuals bent on forcing the government to concede to their whims or suffer deadly consequences. These radicals have developed and released a doomsday germ, but have lost control as it continues to mutate and has become resistant to known cures.

Lou finds himself in a pickle.
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