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Solgar Folate 800 mcg (as Metafolin)- 100 Tablets

4.6 out of 5 stars 188 customer reviews
| 7 answered questions
About the Product
  • Solgar

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Product Description

Size: 100

Folate 800 mcg (as Metafolin) by Solgar 100 Tablet Folate 800 mcg (as Metafolin) 100 Tablet Product Folic Acid must first be converted to its active form by a series of biochemical steps before it is able to be used by the body. Metafolin (L-methylfolate) requires no conversion because it is bioidentical to the bio-active form. In other words it is body-ready. This can be useful for individuals whose bodies have difficulty converting folic acid to its active form. The active folate in this formulation promotes heart health. It also supports a healthy nervous system and the formation of healthy red blood cells. Suggested Use As a dietary supplement adults take one (1) tablet daily preferably at mealtime - Or as directed by your healthcare professional. Supplement Facts Serving Size 1 Tablet Servings Per Container 100 Amount Per Serving Daily Value Folate (as L-methylfolate-Metafolin) 800 mcg 200 Percent Daily Values are based on a 2 000 calorie diet Other Ingredients Mannitol Microcrys

Product Details

Size: 100
  • Product Dimensions: 2 x 2 x 3.4 inches
  • Shipping Weight: 3.5 ounces (View shipping rates and policies)
  • ASIN: B001LR2RVQ
  • UPC: 033984019454
  • Item model number: 033984019454
  • Average Customer Review: 4.6 out of 5 stars  See all reviews (188 customer reviews)
  • Amazon Best Sellers Rank: #2,644 in Health & Personal Care (See Top 100 in Health & Personal Care)

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Customer Reviews

Top Customer Reviews

By W. R. Russell Jr. on January 31, 2012
Size: 100 Verified Purchase
If you're one of the 40 - 60% of people that have some form of defect in one or both of the genes responsible for methylation (MTHFR polymorphism) and you want to try and bypass that blockage to get your methylation system back up to speed, then Metafolin (aka: 5-methyltetrahydrofolate, 5-MTHF, levomefolic acid, or l-methylfolate) is a vital part of the protocol. This is the form ultimately used by the body. If you're an ineffective methylator, it's also the one that works, because your body doesn't have to convert it further to be useful. If you're of caucasian, hispanic, or Mediterranean descent, or have a high IQ, your odds are higher.

This version (Metafolin) is the OTC strength (800 mcg) of the prescription Deplin (7.5 mg), but both are essentially the fully reduced (by methylation - what else) version of folate that the body actually uses...there are a number of enzyme mediated steps in converting folic acid and folates to the useable methylated form. It is also the only one that will cross the blood-brain barrier. Merck apparently figured out how to do the same thing and came up with a bioidentical form...and then patented their process for making it. I'm sure they knew about the distribution of the polymorphism and how big the market would be. I'm a business major, not a doctor. Props to Merck here, not slams.

This is one of the few times that I think a pharmaceutical company may have gotten it right and should serve as a lesson to the others...vitamins and minerals in their most useable forms are curative medicines...curative...they cure diseases...not just treat them. Name one man made synthetic drug, not based on copying a biological compound, that has that claim.
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Size: 100 Verified Purchase
The Basics: What You Need To Know About Folic Acid & Folate:

Folic acid (synthetic vitamin B-9) is a water-soluble B vitamin that is essential for the maintenance of cellular functions, the production of red blood cells (erythrocytes), and for helping to synthesize and repair and methylate DNA, the molecule that encodes our genes. As such, it plays a critical role in promoting optimal cardiovascular and nervous system health. Folic acid is the chemically produced, oxidized and un-methylated form of folate used in many commercially-prepared fortified foods, breakfast cereals and supplements. In order to be effectively used by the body however, folic acid must first be converted to tetrahydrofolate (tetrahydrofolic acid) by dihydrofolate reductase (DHFR)-the reduced or methylated form. Folic acid may not become fully converted or metabolized. The excess folic acid becomes oxidized and unstable, promoting free radical production potentially leading to cancer and other disease. Increasing evidence suggests that this conversion process may be slow and challenging for us.

Folate (natural vitamin B-9), is primarily found in fruits and vegetables, specifically dark, leafy greens and beans, hence its name “folate” from the Latin “folium” (foliage) which means “leaf”. Our bodies cannot produce folic acid or folate so it must be supplied through our diet or from dietary supplementation. Folate is the biologically active and the only form that can penetrate the blood-brain barrier. Folate enters our normal biochemical pathways and becomes efficiently and effectively metabolized unlike folic acid which requires conversion in order to be assimilated by our bodies.
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Size: 100 Verified Purchase
Yes I have the MTHFR 677CT mutation (heterozygous) and have been taking Deplin since it first came out in 2008. I have tried other brands and nothing came close to working like Solgar's Folate. As time has gone I have been able to switch to Solgar Brand, and have reduced the deplin to 7.5mg and some days only take the Solgar 2X a day. I have researched Folate over the last five years and found that I respond better to Metafolin and to other forms of active folate sold over the counter, why I don't know and really don't care...Try this if you are looking for a cheaper alternative to Deplin, maybe you will repond like I have. Nothing short of a miracle.....
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Size: 100 Verified Purchase
Metafolin is well known for augmenting antidepressants and as a behavioral health professional, I feel I can accurately speak to its efficacy. We use it frequently to boost neurotransmitter production and make antidepressants more effective. that said, this is a cost effective alternative to the expensive versions and it works well.
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Size: 100 Verified Purchase
YES, THIS IS THE STUFF YOU WANT!!!! I was researching my daughter's autism, and have been studying methylation, and lowering homocysteine and inflammation. Every time I get something to try for my daughter, I try it first for taste, side effects, how will it make me feel, etc. I, myself, am old, fat, in my forties...failing thyroid, losing hair, blurred vision, and just feeling bad, in general. So, when they came in the mail, I took one with some oj, and waited. Slowly, I began to realize I had a little pep. I was feeling as run down as usual. I actually started feeling better!!! Then I thought, if one is good....you know how it goes. I then gave some to my daughter. I noticed a little pep in her step too! And, although she can't talk, she went to bed with an unusual smile on her face, and actually fell asleep kind of early this evening. I will continue to take this, and give it to my daughter. If I notice any real changes, or anything exciting to tell, I'll try to come back and give an update. ....fingers crossed...
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