Solgar Folate 800 mcg (as Metafolin)- 100 Tablets
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Top Customer Reviews
This version (Metafolin) is the OTC strength (800 mcg) of the prescription Deplin (7.5 mg), but both are essentially the fully reduced (by methylation - what else) version of folate that the body actually uses...there are a number of enzyme mediated steps in converting folic acid and folates to the useable methylated form. It is also the only one that will cross the blood-brain barrier. Merck apparently figured out how to do the same thing and came up with a bioidentical form...and then patented their process for making it. I'm sure they knew about the distribution of the polymorphism and how big the market would be. I'm a business major, not a doctor. Props to Merck here, not slams.
This is one of the few times that I think a pharmaceutical company may have gotten it right and should serve as a lesson to the others...vitamins and minerals in their most useable forms are curative medicines...curative...they cure diseases...not just treat them. Name one man made synthetic drug, not based on copying a biological compound, that has that claim.Read more ›
Folic acid (synthetic vitamin B-9) is a water-soluble B vitamin that is essential for the maintenance of cellular functions, the production of red blood cells (erythrocytes), and for helping to synthesize and repair and methylate DNA, the molecule that encodes our genes. As such, it plays a critical role in promoting optimal cardiovascular and nervous system health. Folic acid is the chemically produced, oxidized and un-methylated form of folate used in many commercially-prepared fortified foods, breakfast cereals and supplements. In order to be effectively used by the body however, folic acid must first be converted to tetrahydrofolate (tetrahydrofolic acid) by dihydrofolate reductase (DHFR)-the reduced or methylated form. Folic acid may not become fully converted or metabolized. The excess folic acid becomes oxidized and unstable, promoting free radical production potentially leading to cancer and other disease. Increasing evidence suggests that this conversion process may be slow and challenging for us.
Folate (natural vitamin B-9), is primarily found in fruits and vegetables, specifically dark, leafy greens and beans, hence its name “folate” from the Latin “folium” (foliage) which means “leaf”. Our bodies cannot produce folic acid or folate so it must be supplied through our diet or from dietary supplementation. Folate is the biologically active and the only form that can penetrate the blood-brain barrier. Folate enters our normal biochemical pathways and becomes efficiently and effectively metabolized unlike folic acid which requires conversion in order to be assimilated by our bodies.Read more ›
Most Recent Customer Reviews
My functional NP reccommends this product and I have been very happy with it. Folate is very important to take for pregnanacy and trying to conceive.Published 3 days ago by Derek Hartman
Works well if you have a genetic marker for depression and need more methylfolate in your system.Published 13 days ago by Christopher Jones
I found I don't process Folic Acid and these are perfect. Great quality bottle and they don't make me sick.Published 14 days ago by AngB
This stuff is the real deal. Everyone is different, but for me, I find that taking it before bed is ideal. This stuff makes my legs feel kind of like lead, but in a good way. Read morePublished 18 days ago by Elisabeth Z Meyers
This is like natures crack. I AM SO HAPPY within hours of taking this. Mind and body BLOWN. My Dr. told me I was lacking in several essential vitamins- folate (not folic acid,big... Read morePublished 22 days ago by l.a. mom