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Stop the Clock: The Optimal Anti-Aging Strategy Paperback – June 18, 2015
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stressed use of or natural means to produce HGH
I consider several of Mangan's books -- this one foremost among them -- simply essential to maximizing and optimizing health. For anyone familiar with Mangan over the years, the example of his own transformation is proof of his seriousness and offers motivation for anyone who is pessimisstic about the possibility for personal change.
What we're left with is DNA damage accrued over a lifetime. I think that the diet, lifestyle and supplements that Mangan recommends are most beneficial to combat neurodegenerative disease and optimize cognitive performance .This is the case because neurons are relatively unaffected by mutations that occur in adulthood. This is the vast majority of neurons (>99.9%) are fixed and non-dividing, which prevents them from propagating errors in DNA to other neurons. Hence, a mutation in a particular neuron is not spread the same way a mutation can cause leukemia because all blood cells become affected.
Grumpy Scientist's review is unnecessarily vitriolic. The reviewer himself acknowledges that that many of the ideas that Mangan develops in the book are evidence-based and accurate. The fact that Grumpy Scientist takes issue with carb restriction is interesting, because calorie restriction in general (and particularly carb restriction) is one of the most robust and reproducible life-extension strategies. It's increasingly clear that even low-grade hyperglycemia from excess sugar will erode insulin resistance and have a number of downstream deleterious effects. For example, many think that Alzheimer's disease is essentially type 3 diabetes, though this idea is controversial.
Which makes this the best diet book I've read in the past ten years.