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The Tangled Tree: A Radical New History of Life Kindle Edition
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In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important; we now know that roughly eight percent of the human genome arrived sideways by viral infection—a type of HGT.
In The Tangled Tree, “the grandest tale in biology….David Quammen presents the science—and the scientists involved—with patience, candor, and flair” (Nature). We learn about the major players, such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.
“David Quammen proves to be an immensely well-informed guide to a complex story” (The Wall Street Journal). In The Tangled Tree, he explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life—including where we humans fit upon it. Thanks to new technologies, we now have the ability to alter even our genetic composition—through sideways insertions, as nature has long been doing. “The Tangled Tree is a source of wonder….Quammen has written a deep and daring intellectual adventure” (The Boston Globe).
- LanguageEnglish
- PublisherSimon & Schuster
- Publication dateAugust 14, 2018
- File size13332 KB
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Editorial Reviews
Review
“David Quammen’s diligently researched and deeply considered overview of what’s been going on recently in evolutionary biology is illuminating, wondrous, and gripping. Also scary when it comes to thinking about the evolution of Homo sapiens. This is stunning, first-rate journalism.” (Barry Lopez, author of Arctic Dreams )
“There's no one who writes about complex science better than David Quammen. The Tangled Tree is at once fascinating, illuminating, and totally absorbing.” (Elizabeth Kolbert, author of the Pulitzer Prize-winning The Sixth Extinction )
“Quammen has written a deep and daring intellectual adventure. . . . The Tangled Tree is much more than a report on some cool new scientific facts. It is, rather, a source of wonder.” (Thomas Levenson The Boston Globe)
“David Quammen proves to be an immensely well-informed guide to a complex story. . . . Indeed he is, in my opinion, the best natural history writer currently working. Mr. Quammen’s books . . . consistently impress with their accuracy, energy and superb, evocative writing." (David Barash The Wall Street Journal)
"In The Tangled Tree, celebrated science writer David Quammen tells perhaps the grandest tale in biology. . . . He presents the science — and the scientists involved — with patience, candour and flair." (John Archibald Nature)
"A lively account of how new genetic research is upending the fundamental history of life." (Andrea Thompson Scientific American)
"In David Quammen’s new page turner, The Tangled Tree: A Radical New History of Life, the author reveals how new molecular techniques have come to revolutionize the way we understand evolutionary processes and how we classify life into coherent groups. In an accessible style that has won him accolades in the past, Quammen does a marvelous job of weaving together the scientific and human story of this revolution. . . . Quammen has once again crafted a delightful read on a complex and important subject." (Ivor T. Knight Science)
"With humor, clarity, and exciting accounts of breakthroughs and feuds, Quammen traces the painstaking revelation of life’s truly spectacular complexity." (Booklist (starred review))
"One of the central insights in Charles Darwin's theory of evolution was that life branched like a tree. And one of the revolutionary discoveries of molecular biology over a century later was that the tree of life was, in fact, a far more complex maze of branches. In The Tangled Tree, David Quammen offers the definitive chronicle of this profound development in our understanding of the history of life." (Carl Zimmer, author of She Has Her Mother's Laugh and Parasite Rex )
“A masterful history of a new field of molecular biology . . . . [An] impressive account of perhaps the most unheralded scientific revolution of the 20th century. . . . A consistently engaging collection of vivid portraits of brilliant, driven, quarrelsome scientists in the process of dramatically altering the fundamentals of evolution, illuminated by the author's insightful commentary.” (Kirkus Reviews (starred review))
"[Quammen] explores important questions and makes the process as well as the findings understandable and exciting to lay readers. . . . This book also proves its author's mastery in weaving various strands of a complex story into an intricate, beautiful, and gripping whole." (Publishers Weekly (starred review))
“[Quammen] writes like the director of a summer blockbuster: blasts of rich detail, quick cuts, not a second wasted.” (Lois Beckett The Guardian)
About the Author
Product details
- ASIN : B075RX2QY4
- Publisher : Simon & Schuster; Reprint edition (August 14, 2018)
- Publication date : August 14, 2018
- Language : English
- File size : 13332 KB
- Text-to-Speech : Enabled
- Screen Reader : Supported
- Enhanced typesetting : Enabled
- X-Ray : Enabled
- Word Wise : Enabled
- Sticky notes : On Kindle Scribe
- Print length : 490 pages
- Page numbers source ISBN : 1476776636
- Best Sellers Rank: #228,438 in Kindle Store (See Top 100 in Kindle Store)
- #51 in Genetic Science
- #61 in Zoology (Kindle Store)
- #160 in Evolution (Kindle Store)
- Customer Reviews:
About the author

David Quammen is the author of a dozen fiction and nonfiction books, including Blood Line and The Song of the Dodo. Spillover, his most recent book, was shortlisted for several major awards. A three-time National Magazine Award winner, he is a contributing writer for National Geographic and has written also for Harper’s, Outside, Esquire, The Atlantic, Powder, and Rolling Stone. He travels widely on assignment, usually to jungles, mountains, remote islands, and swamps.
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Yes, all began with a tree. You can see that in a figure drawn by Darwin himself in one of his notebooks (1837). The drawing is accompanied by a note that says, "I think" (p. 8).
But as time went by, that tree began to suffer some transformations. New suggestions, and new insights based on new discoveries, opened that tree in several branches and, why not, more trunks. Darwin's drawing presented just one trunk, not three as Carl Woese put it in 1987, only without roots in the ground. There was not a singular and a unique origin.
The discovery of the DNA molecule opened more and more possibilities and questions. Nobody was quiet or felt comfortable in the multitude of labs and seminars around the world. There, in the DNA molecule, there was something hidden, and that something (to me the very swerve of the story) was the discovery of the Horizontal Gene Transfer (HGT). In a sentence: HGT meant that the tree wasn't a tree, it was a hedge. There was not only vertical influence (mutations and so on) from parents to sons, but also horizontal influence among species.
Genes are not only inherited from ancestors; in fact we receive them from viruses or bacteria that move around us. And this is happening all the time. So, what are we in the end? What are species?
David Quammen has made a superb work in this book (390 pages before Notes). He interviewed numerous actors of this adventure movie. Some of them are dead, so Quammen looked for disciples and friends in order to complete his own tangled tree.
I don't know what is better in this narrative if the actors or the fascinating story the author tells us (he could have done it without this human element). Hard to say. Quammen is so good a narrator, one of those that go with you all the way through the end. He works for you! You almost not need to think. (Well, almost).
Everything in this wonderful exposition of facts, heroes, battles, failures and successes, is intended to be clearly understood. Bottom line: evolution is happening but not as in a tree. Is occurring in parallel, everywhere and all the time. You'll discover by yourself the richness and variety of life as you never saw it. This is new, this is what’s happening today in molecular biology.
Now I'm going to read the last book by the same author, "Breathless."
And a final note: if you're in doubt with respect to the dissonance that Quammen could have produced within the Darwinian Brotherhood, I would say, don't worry. He has been welcomed by them.
That's how science works. Darwin would have been happy.
By Odysseus at home on November 1, 2022
Yes, all began with a tree. You can see that in a figure drawn by Darwin himself in one of his notebooks (1837). The drawing is accompanied by a note that says, "I think" (p. 8).
But as time went by, that tree began to suffer some transformations. New suggestions, and new insights based on new discoveries, opened that tree in several branches and, why not, more trunks. Darwin's drawing presented just one trunk, not three as Carl Woese put it in 1987, only without roots in the ground. There was not a singular and a unique origin.
The discovery of the DNA molecule opened more and more possibilities and questions. Nobody was quiet or felt comfortable in the multitude of labs and seminars around the world. There, in the DNA molecule, there was something hidden, and that something (to me the very swerve of the story) was the discovery of the Horizontal Gene Transfer (HGT). In a sentence: HGT meant that the tree wasn't a tree, it was a hedge. There was not only vertical influence (mutations and so on) from parents to sons, but also horizontal influence among species.
Genes are not only inherited from ancestors; in fact we receive them from viruses or bacteria that move around us. And this is happening all the time. So, what are we in the end? What are species?
David Quammen has made a superb work in this book (390 pages before Notes). He interviewed numerous actors of this adventure movie. Some of them are dead, so Quammen looked for disciples and friends in order to complete his own tangled tree.
I don't know what is better in this narrative if the actors or the fascinating story the author tells us (he could have done it without this human element). Hard to say. Quammen is so good a narrator, one of those that go with you all the way through the end. He works for you! You almost not need to think. (Well, almost).
Everything in this wonderful exposition of facts, heroes, battles, failures and successes, is intended to be clearly understood. Bottom line: evolution is happening but not as in a tree. Is occurring in parallel, everywhere and all the time. You'll discover by yourself the richness and variety of life as you never saw it. This is new, this is what’s happening today in molecular biology.
Now I'm going to read the last book by the same author, "Breathless."
And a final note: if you're in doubt with respect to the dissonance that Quammen could have produced within the Darwinian Brotherhood, I would say, don't worry. He has been welcomed by them.
That's how science works. Darwin would have been happy.
The Tangled Tree doesn't really follow a clear path with clear goals for the book. It covers the figures who have updated our views of how life emerged and how evolution has occurred. The author discusses of course the Darwinian view of survival of the fittest and the original tree of life diagrams that figuratively shaped our intuition about the branching nature of biology but quickly moves on to how this is erroneous. The author spends a lot of time talking about Carl Woese who first proposed Archae as a separate branch of life and discussed the chemical traces that could be used to understand the relationships among biological units. The reader gets a sense of the techniques used in modern biology that took the field from looking qualitatively at structures to infer relationships to quantitatively analyzing biochemistry to understand divergences between chemical structures. With such methodological improvements the author weaves in the main concepts of the book which entail horizontal gene transfer. The main conceptual takeaways for the reader come from the idea that improvements in genome don't happen through a clear survival of the fittest evolutionary process but rather that horizontal gene transfer is alive and well and how most genetic material at the single cell level has occurred and led to massive changes. Included in this concept is the inclusion of mitochondrial DNA in our own cells along with countless other examples. The author discusses the ideological battles fought on the relevance of horizontal gene transfer and whether its influence extended after life gained complexity but the consequence of horizontal gene transfer from a visual perspective is that the tree of life is more of a brambled bush. The author weaves together the lives of multiple scientists who worked on evolving our ideas on evolution and the origin of life, a lot centering on Carl Woese, but this is the story that carries the weight of the book.
The Tangled Tree introduces ideas which have been around but still subordinated to the tree of life picture of evolution in an entertaining and readable form. The book is not structured particularly effectively and sometimes has sub chapters on the order of 1 page or so, as such the writing doesn't often flow particularly well. Overall thought it is easy to follow and the content is conveyed. If one wants to read an entertaining account of our modern take on the tree of life, this is a worthwhile read.
Top reviews from other countries
This review sounds more negative than the book deserves. It's still very readable and full of the usual surprising facts, but doesn't scale the heights that Quammen is capable of - something that left me slightly disappointed.
This is really a book around two main themes - a man, Carl Woese and a field of study -Horizontal Gene Transfer. It gives very little technical detai lbut is primarily interested in the people involved and goes backwards and forwards in time until you've almost lost track of what the point of it all was. But the biographical details of the many, many people involved is interesting and I did get the main thrust which is that Horizontal Gene Transfer is important. However it was unclear at the end as to how important this is to evolutionary theory - i.e. is is 90% or 10%? I suspect the answer is we just don't know. i wonder if it relates to the ideas of punctuated equilibria that Steven Jay Gould used to support? What exactly is Richard Dawkins position on it all ? At the moment it seems there is a lot still unknown.
Using this detailed research gleaned over 4 years of travel, study and interviews, Quammen guides us from Darwin’s early theories of evolution in which life branched like a tree to the latest discoveries suggesting a more appropriate analogy of The Web of Life. He explains in meticulous detail how molecular biology and phylogenics have pieced together the evolution of simple single-cell prokaryotes into complex multi-celled eukaryotes, and even suggests how the primeval chemical mix combined to form amino acids to create RNA – the basis of all life on Earth.
And some of his revelations are truly stunning. Such as the discovery of endosymbiosis – the implications of which make us humans wonder exactly what and who we are. Especially when learning that 8% (one twelfth!) of the human genome is from retroviruses.....
This complex subject is explained with such clarity and enthusiasm that I could not put the book down. And I didn’t want to finish it. I unreservedly recommend The Tangled Tree – if you read and absorb this book you will know more about the origins and evolution of life than 99.999% of the world’s population! If there were more than 5 stars I would award them.
For many, I imagine, this book might be a disappointment (or pleasant surprise); unlike many more typical science books Quammen elects to tell his science through the lives of the scientists who made the discoveries in question. In many ways the book is as much a book on the history of science as it is on the science itself. Personally, and as someone who has training in both biology and in the history of science, I love this particular angle Quammen takes, but others might value a more straightforward approach. That said, the book is highly readable, full of surprising facts and superbly written. I recommend this book highly to anyone interested in life, genetics and the history of one of science’s more important developments in recent years. Five stars.
Reviewed in the United Kingdom 🇬🇧 on April 10, 2019
For many, I imagine, this book might be a disappointment (or pleasant surprise); unlike many more typical science books Quammen elects to tell his science through the lives of the scientists who made the discoveries in question. In many ways the book is as much a book on the history of science as it is on the science itself. Personally, and as someone who has training in both biology and in the history of science, I love this particular angle Quammen takes, but others might value a more straightforward approach. That said, the book is highly readable, full of surprising facts and superbly written. I recommend this book highly to anyone interested in life, genetics and the history of one of science’s more important developments in recent years. Five stars.









