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Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition by [Derrick Lonsdale, Chandler Marrs]

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Derrick Lonsdale

Chandler Marrs

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition 1st Edition, Kindle Edition

by Derrick Lonsdale (Author), Chandler Marrs (Author) Format: Kindle Edition

4.8 126 ratings

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Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria. Thiamine deficiency derails mitochondrial oxidative metabolism and gives rise to the classic disease of beriberi that, in its early stages, can be considered the prototype for a set of disorders that we now recognize as dysautonomia. This book represents the life’s work of the senior author, Dr. Derrick Lonsdale, and a recent collaboration with his co-author Dr. Chandler Marrs.

Presents clinical experience and animal research that have answered questions about thiamine chemistry
Demonstrates that the consumption of empty calories can result in clinical effects that lead to misdiagnosis
Addresses the biochemical changes induced by vitamin deficiency, particularly that of thiamine

ISBN-13

978-0128103876
Edition

1st
Sticky notes

On Kindle Scribe
Publisher

Academic Press
Publication date

June 29, 2017
Language

English
File size

27814 KB
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Editorial Reviews

About the Author

Dr. Lonsdale was educated in England, graduating from London University with the degree MB BS. After National Service in the RAF as a medical officer he became a family physician under the National Health Service. He immigrated to Canada in 1957 and in 1960 he was accepted as a pediatric resident at Cleveland Clinic, Cleveland, Ohio. In 1962 he was appointed to the pediatric staff where his clinical research led to his commitment to uncovering the connections between thiamin metabolism and metabolic brain disease. Before retirement he was a Fellow of the American College of nutrition and a Certified Nutrition Specialist.

Dr. Marrs received a BA in philosophy and then spent many years in the tech industry before returning to academia for an MS in Clinical Psychology and an MA and PhD in Experimental Psychology with an emphasis in neuroendocrinology. Recognizing the lack of women’s health and hormone research, Dr. Marrs founded Lucine Health Sciences, a health research and media company that publishes the online journal Hormones Matter and conducts post-market, direct-to-patient medication safety and efficacy studies. --This text refers to the paperback edition.

Review

A presentation of the latest research on high calorie malnutrition and thiamine deficiency, which contribute to many pediatric illnesses

--This text refers to the paperback edition.

Product details

ASIN ‏ : ‎ B073NCFNLX
Publisher ‏ : ‎ Academic Press; 1st edition (June 29, 2017)
Publication date ‏ : ‎ June 29, 2017
Language ‏ : ‎ English
File size ‏ : ‎ 27814 KB
Text-to-Speech ‏ : ‎ Enabled
Screen Reader ‏ : ‎ Supported
Enhanced typesetting ‏ : ‎ Enabled
X-Ray ‏ : ‎ Not Enabled
Word Wise ‏ : ‎ Not Enabled
Sticky notes ‏ : ‎ On Kindle Scribe
Print length ‏ : ‎ 343 pages

Best Sellers Rank: #216,343 in Kindle Store (See Top 100 in Kindle Store)
- #37 in Medical Nutrition (Kindle Store)
- #204 in Nutrition (Kindle Store)
- #1,000 in Nutrition (Books)

Customer Reviews:
4.8 126 ratings

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Derrick Lonsdale
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Chandler Marrs
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Chandler Marrs, PhD, is proud mom of 23 year old twins, a research scientist and fierce women’s health advocate. She has spent the last 20 years in women’s health research, first in perinatal mental health and hormones and more recently in medication induced mitochondrial dysfunction. She is prolific writer with well over 200 articles on a range of health topics published on her blog Hormones Matter. This is her first book.
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Customer reviews

4.8 out of 5

126 global ratings

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4 star		3%
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john b. smith

Be a Fool

Reviewed in the United States 🇺🇸 on May 1, 2023

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Dr. Osler is reputed to have said, "any man who is his own doctor has a fool for a patient". Modern medicine forces us to be "fools". Save yourself, read this book.

4 people found this helpful

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Erin

This book is a miracle!

Reviewed in the United States 🇺🇸 on December 13, 2017

Verified Purchase

As a patient, this book has really opened my eyes. For over two years now, I’ve suffered from debilitating symptoms due an adverse drug reaction to metronidazole (aka, Flagyl). These symptoms mysteriously wax and wane—some days I barely notice them and then, due to a mild illness or physical exertion, they resurface, sometimes forcing me to back to bed to rest and recoup for days at a time or longer.

When I was taking the drug, I lost the ability to walk and speak, along with a dozen other symptoms. Even when I discontinued, almost all of the symptoms persisted. I would later realize that, if you lose the ability to walk and speak while taking metronidazole, there’s almost a 100% chance lesions have formed on the back of your brain, specifically the cerebellum, with the brain stem being the second most-hit region. It's called "metronidazole-induced central nervous system toxicity."

Along with the walking/speaking issues (I’d later learn were caused by cerebellar dysfunction), there were also several autonomic issues like difficulty swallowing, constipation, respiratory issues (it felt like my brain forgot how to breathe correctly, which resulted in me having a borderline enlarged heart), severe anxiety, insomnia, depression, heart palpitations, chest pressure, and several other problems.

Every single one of my symptoms is listed in this book. It even explains why they keep flaring up.

Doing more research, I discovered that metronidazole and thiamine are antagonists; the drug inhibits thiamine from being absorbed in the body and plummets the body into deficiency. In medical literature, metronidazole toxicity is constantly being compared to another type of brain dysfunction, Wernicke’s encephalopathy. This is because the symptoms and the lesions on the back of the brain are strikingly similar, and these two conditions are continuously compared to one another. Wernicke’s is caused directly by thiamine deficiency.

I suffered a major flare up this November; as I dealt with its effects, that’s when I happened upon this book. I started on a thiamine/magnesium regimen, and my flare up has calmed down at record speed. It’s gone from debilitating (I missed several days of work) to mild, where I’m able to work and function in social activities. I still have a long way to go, but I’ve never recovered this fast from a flare up before.

Unfortunately, there are no doctors to guide patients like me. I’ve discovered the hard way that doctors don’t believe in adverse drug reactions; not only will they not treat the condition, they won’t acknowledge it exists. I started a support group for people who suffer from metronidazole toxicity; when I created it, there were three of us. Now there’s over a hundred. All of us have the same symptoms. Only one member in the group has a doctor who believes her. We even have to warn new members how their doctors will react, in hopes it will prepare them for the reality of being dismissed by the medical community.

Now, we might finally have some answers, and a way to treat our condition. Thank you, Dr. Marrs and Lonsdale for all the hard work and dedication to give us this knowledge! Research like yours saves lives!

259 people found this helpful

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Tiago H.

Everyone should read this book

Reviewed in the United States 🇺🇸 on January 1, 2023

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Don’t let the price of the book prevent you from getting this life saving information. Should be mandatory reading for both Doctors and patients. Be sure to also check the authors site, Hormones Matter and the interviews on youtube

14 people found this helpful

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Teri L. Tetzel

Get the word out about the truthfulness found in this educational material.

Reviewed in the United States 🇺🇸 on January 15, 2023

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Dr. Derrick Lonsdale is ahead of his time and provided truthful, natural health and wellness education.

4 people found this helpful

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Patrick

Crucial Book

Reviewed in the United States 🇺🇸 on December 28, 2022

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This book is groundbreaking and is essential reading for those with thiamine issues

4 people found this helpful

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LawReader

This book was a true miracle for me,

Reviewed in the United States 🇺🇸 on July 21, 2021

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I struggled for about five years with dysautonomia, getting worse all the time, and chronically fatigued. I had testing in Boston - a right heart catheterization and CPET test. I was told by Dr. Systrom that I had a POTS like dysautonomia, small fiber neuropathy, and mitochondrial disorder. I followed advice of using a recumbent bike everyday. However, as I continued to be ill, I received more and more medication. No one took the time to see if I had something like a vitamin deficiency was causing my illness. Thank God for this book! I started high dose B1 treatment, and within three weeks most all of my symptoms lifted. I am now in the process of weaning off all the medications I was put on. Three meds I was able to just stop cold turkey. I lost five years of my life to this B1 deficiency! I thank the fine authors for understanding how nutritional deficiencies weak havoc on our bodies! With all the expensive testing and specialist visits, my doctors missed this common deficiency.

61 people found this helpful

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Jean Arnold

Crucial info for resolving / helping many chronic illnesses

Reviewed in the United States 🇺🇸 on September 21, 2021

Verified Purchase

Thiamine is a crucial nutrient in many processes in our bodies. Its deficiency is very common, yet overlooked in nearly all medical venues, even in nutritionally-oriented functional medicine. Yet deficiency can cause quite a number of severe, even life-threatening symptoms and issues. Many things can cause deficiency. This definitive book explains thiamine's roles and the various pathologies associated with deficiency. It is the culmination of Dr Lonsdale's decades-long research and patient treatment in his work at the Cleveland Clinic. While there is much technical language, Lonsdale & Marrs have endeavored to also make it more understandable for the layperson. Vital information for those struggling with complex chronic health issues and for practitioners working to help such patients. Perhaps even more relevant now in the era of long-haul-covid, as evidence points to the depletion of thiamine as one crucial factor in this mysterious illness.

28 people found this helpful

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Kathleen Riley

If only MDs knew about this condition...

Reviewed in the United States 🇺🇸 on June 7, 2021

Verified Purchase

This book summarizes the life work of a brilliant medical doctor, Derrick Lonsdale, who thinks outside of the box and who realizes what nutritional deficiencies can do. His research and clinical case studies are amazing. After reading this book and doing genealogical research, I have found that my family has suffered from thiamine deficiency on both sides. Both my parents spent their lives tired and weak. Both suffered from preventable conditions in old age that left them to decline in a nursing home. I feel so fortunate to have found this book and to have healthcare professionals who "get" the importance of good nutrition. The co-author and writer of Dr. Lonsdale's work, Chandler Marrs, has done a wonderful job of compiling the research and case studies. Her continuing work on her blog helps others with nutritional challenges and hormone imbalances.

21 people found this helpful

Helpful

Top reviews from other countries

Simon

Well worth the Money!

Reviewed in Australia 🇦🇺 on August 22, 2017

Verified Purchase

Even though I paid for the more expensive price for this book, i was happy to.

Given this is the sum of the life's work and research into this topic from Dr Derrick Lonsdale, who, by the way, still writes about this subject, with such passion well into his 90's, really deserves the price.

While in the past many suffered from malnutrition deficiencies, we are now seeing the converse of this with high calorie malnutrition.

This book outlays the entire model on how many of the "common" diseases, seen in the 21st century, is a result of this high calorie malnutrition, with Thiamine acting as a gatekeeper all the way down to the mitochondrial level.

I highly recommend this book, from my hero Dr Derrick Lonsdale and his co author on this Dr Chandler Marrs.

Thank you both.

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