Price: $46.35 ($0.52 / Count) & FREE Shipping on orders over $49. Details
In Stock. Sold by iServe Products and Fulfilled by Amazon. Gift-wrap available.

One-time purchase:

Thorne Research - Methyl-... has been added to your Cart
Qty:1

Other Sellers on Amazon
Add to Cart
$55.01 ($0.61 / Count)
+ Free Shipping
Sold by: iHealth USA

Save up to 15% on Optimum Nutrition When You Subscribe

Thorne Research - Methyl-Guard Plus - 90 Capsules

4.8 out of 5 stars 117 customer reviews
| 22 answered questions
About the Product
  • Contains higher amounts of 5-MTHF (active folate), B6, B12 per capsule than the original Methyl-Guard
  • Riboflavin 5-phosphate added for extra homocysteine metabolism support
  • Supports healthy heart, blood vessel, brain and nerve function and bone health
  • Easy 3 capsule daily dosing

Frequently Bought Together

  • Thorne Research - Methyl-Guard Plus - 90 Capsules
  • +
  • Thorne Research - Vitamin D-5000 - Vitamin D3 Supplement - 60 Capsules
Total price: $60.34
Buy the selected items together


Product Description

Size: 90 VegiCaps | Product Packaging: Standard Packaging

More concentrated methylation support. Since 1984, Thorne Research has set the standard for exceptional formulation and quality manufacturing of premium nutritional supplements. Thorne Research is dedicated to enhancing the health and wellbeing of individuals worldwide by providing innovative, high-quality, research-based nutritional supplements, health diagnostics technology platforms, and the latest in medical education. With more than 350 products, Thorne Research is recognized by health-care practitioners as a global leader in providing nutritional supplements of the highest quality and purity. Thorne Research is the only nutritional supplement manufacturer that has been authorized to include health and lifestyle content on its website that has been authored by the Mayo Clinic. Thorne Research products do not contain Genetically Modified Organisms (GMOs) nor any binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption. In addition, Thorne Research has received the prestigious NSF International general Good Manufacturing Practices (GMP) and Certified for Sport certifications. Select products that receive the NSF Certified for Sport certification enables athletes, coaches, and trainers to make informed decisions when choosing nutritional supplements for sports performance.

Product Details

Size: 90 VegiCaps | Package Type: Standard Packaging
  • Product Dimensions: 0.8 x 0.8 x 0.8 inches ; 3.8 pounds
  • Shipping Weight: 4 ounces (View shipping rates and policies)
  • Domestic Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • International Shipping: This item is not eligible for international shipping. Learn More
  • ASIN: B00O5AHC4S
  • UPC: 693749789017 701627510421 882855267766 884967152206 885786045052
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (117 customer reviews)
  • Amazon Best Sellers Rank: #1,594 in Health & Personal Care (See Top 100 in Health & Personal Care)

Important Information

Safety Information
If pregnant, consult your health-care practitioner before using this product. 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Directions
Take 1-3 capsules daily or as recommended by a health-care practioner.

Legal Disclaimer
These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Please see our full disclaimer below.

Customer Questions & Answers

Customer Reviews

Top Customer Reviews

Size: 90 VegiCapsPackage Type: Standard Packaging
Been diagnosed with 1 copy each of the C677T & A1298C mutant genes. Dr has me taking this brand. I began taking 3-4 per day and ran out of energy, so we reduced my intake to zero for 3 days (to allow my body to stop detoxing so rapidly). Then on day 4 I took 1 capsule and am maintaining a good level of energy. I might increase to two per day as time progresses. My body has gone 60+ years without methylating...........and it shows. So this new regimen is taking time to rebuild my muscles and immune system once again.
5 Comments 70 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging
I have been recently diagnosed with MTHFR so my ND is having me take it 3 times daily. It is very worth researching the side effects of not being treated for MTHFR Deficiency. To get tested its a simple blood test. NOT treated it can cause many health problems including depression,ADHD, thrombosis and leukemia. I have been trying to get pregnant and not until treated I was able to. Highly recommend this and any THORNE products.
5 Comments 47 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
My naturopath recommended this after I tested positive for the MTHFR gene. I had been dealing with severe anxiety, fatigue and depression for months, and this has absolutely helped. I've never taken supplements ritually, but now I take 2 of these every morning like my life depends on it because I can really tell the difference when I don't take it. I have a lot more energy now.
1 Comment 33 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
After using a genetic testing kit I discovered that I have the MTHFR mutation. I did a lot of research on the methyl version of B-12 and B-6 vitamins and decided to try the Thorne Research Methyl-Guard Plus. I have been taking have been taking the Methyl-Guard Plus for 2 weeks now and it has definitely had a positive impact on my life. The anxiety that I have suffered with for so long has been greatly diminished. I know this is due to the Methyl-Guard Plus because it is the only change I have made in my daily routine. I have also had more energy and I have been sleeping much better at night.

The only complaint I have is how quickly it seemed to get into my system. I started by taking 2 pills each morning and I quickly realized that this was too much. I started having headaches that went away when I switched to one each morning and one in the afternoon. I have now worked myself up to 2 each morning and 1 in the afternoon. This seems to be the perfect combination for me.

I highly recommend this product to anyone who has found out that they have the MTHFR genetic mutation.
Comment 21 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
It has helped me feel more energetic and stop losing hair. It was recommended to me by an integrative MD in my town. I have been taking it for 3 months now.
1 Comment 20 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
some people are genetically incapable of methylating their b vitamins - often those with alcoholics in their family. these actually allow for absorption and use of the vitamin by your body.
3 Comments 20 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
This works! My doctor suggested using to lower inflammation levels. Within two weeks, I began noticing a a very positive change.
1 Comment 13 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse
Size: 90 VegiCapsPackage Type: Standard Packaging Verified Purchase
Wish these were cheaper as I will have to take them for life, but LIFE CHANGING! If you have the MTHFR gene mutation, I can't recommend this vitamin enough. My 85 year old father started taking these too, and has so much more energy! I've been taking about 6 months now. Personally I suffered from Migraines and mental fog and memory loss, not to mention excessive fatigue needing daily naps. My headaches went away within hours of my first dose, my energy increased and I no longer need daily naps, but most important was the brain fog. I was to the point of not being able to solve problems (and I tutor high school math so that is a big problem). Now I teach and tutor without any cognitive problems. I still don't think my memory is what it used to be but not as bad, and everything else is Sooooo much better. If you find out you have the MTHFR gene mutation, this is the vitamin for you. Regular B vitamins wont do it. My mother's Dr. told her to take large amounts of B12 and Folic Acid (for the same mutation) but this is wrong. You don't need more vitamins, you need the RIGHT vitamins. They need to be in the already Methylated form so your body can use them. I'm homozygous for c677t which means I noticed a drastic difference. If you are only heterozygous, you probably won't notice the drastic difference that my father and I did, but I would still recommend as I think it would make a big impact on your overall health.
Comment 12 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
Thank you for your feedback.
Sorry, we failed to record your vote. Please try again
Report abuse

Most Recent Customer Reviews

Set up an Amazon Giveaway

Thorne Research - Methyl-Guard Plus - 90 Capsules
Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers. Learn more about Amazon Giveaway
This item: Thorne Research - Methyl-Guard Plus - 90 Capsules

Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.