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Understanding Coronavirus (Understanding Life) 1st Edition
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- ISBN-101108826717
- ISBN-13978-1108826716
- Edition1st
- PublisherCambridge University Press
- Publication dateJuly 9, 2020
- LanguageEnglish
- Dimensions5 x 0.33 x 7 inches
- Print length120 pages
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Editorial Reviews
Review
'An extremely concise and important book that everyone should read to understand the dynamics of the COVID-19 pandemic.' Siddhartha Mukherjee, Columbia University, New York, and author of The Gene and The Emperor of All Maladies
'Raul Rabadan has written an essential book for the first pandemic of the 21st century, COVID19 caused by SARS-CoV-2. It’s a wonderfully concise and accessible explanation of everything you want to know about the virus, the disease, and the outbreak. If you want to learn what is a coronavirus, how the outbreak started, what are the therapeutic options, and much more, I highly recommend this book. Professor Rabadan explains viruses in a way that is accessible to all.' Vincent Racaniello, Columbia University, New York
‘A much-needed primer that offers basic information … What Understanding Coronavirus does very well is clarify virology and epidemiology basics. Asking how quickly the virus spreads means explaining the basic reproduction number R0 and concepts such as 'flattening the curve' and herd immunity that everyone has been confronted with. It explains the symptoms, the typical course of the disease, how deadly it is, and that, yes, children and young adults get infected too, but their symptoms are usually less severe … Understanding Coronavirus overall provides a lot of relevant information in a very readable and concise format. And at this price, you cannot really go wrong.’ Leon Vlieger, Natural History Book Service
'A clear scientific guide to COVID-19 … (it) illuminates coronavirus science not only with clear writing but also with good graphics and illustrations.' Clive Cookson, Financial Times
'This small book could be required reading for many politicians and journalists …' Tilli Tansey, Nature
Book Description
About the Author
Product details
- Publisher : Cambridge University Press; 1st edition (July 9, 2020)
- Language : English
- Paperback : 120 pages
- ISBN-10 : 1108826717
- ISBN-13 : 978-1108826716
- Item Weight : 4.6 ounces
- Dimensions : 5 x 0.33 x 7 inches
- Best Sellers Rank: #308,389 in Books (See Top 100 in Books)
- #136 in Microbiology (Books)
- #158 in Biology (Books)
- #4,909 in Engineering (Books)
- Customer Reviews:
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About the author

Raul Rabadan is a theoretical physicist and a computational biologist. He is currently a professor in the Departments of Systems Biology and Biomedical Informatics at Columbia University, in the city of New York. He serves as director of the Program for Mathematical Genomics at Columbia University and director NCI Center for Topology of Cancer Evolution and Heterogeneity.
From 2001 to 2003, Dr. Rabadan was a fellow at the Theoretical Physics Division at CERN, the European Organization for Nuclear Research, in Geneva, Switzerland. In 2003 he joined the Physics Group of the School of Natural Sciences at the Institute for Advanced Study. Previously, Dr. Rabadan was the Martin A. and Helen Chooljian Member at The Simons Center for Systems Biology at the Institute for Advanced Study in Princeton, New Jersey. He has been named one of Popular Science's Brilliant 10 (2010), a Stewart Trust Fellow (2013), and he received the Harold and Golden Lamport Award (2014), the Diz-Pintado Award (2018) and the Phillip Sharp Award (2018).
Dr. Rabadan’s current scientific interests revolve around uncovering patterns of evolution in highly dynamic biological systems using large scale genomic data. In particular, his work in the last few years has been focused on understanding how cancers and viruses evolve: how they appear, how they change and how they create therapeutic resistance.
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In the book he is describing what a corona virus is, this particular corona virus (SARS-Cov-2), the genetics/RNA, when it came into existence and likely how, how it is evolving and changing, how it spreads, how it compares with SARS (pretty similar), how it compares with influenza (totally different), he discusses therapeutic options, common misunderstandings and ongoing research. Corona viruses are spherical and have spike proteins used for entering the cell (via ACE2 enzymes). The spike proteins make the viruses look like crowns in electron microscopes, thereof the name. They also have membrane proteins, envelope proteins and a nucleicapsid protein. Corona viruses uses RNA to store their genetic information. That’s what defines a corona virus and there are 100’s of them, 7 infect humans, some are harmless, some are lethal, they have around ~30,000 base pairs.
By looking at the genome for SARS-Cov-2 and how it has changed we can know that it first came into existence in the middle of November 2019 via mutation most likely involving recombination. He explains the difference between infection fatality rate, case fatality rate, mortality rate, and why the estimate for the case fatality rate has changed.
The author dedicates chapter six to a comparison with the SARS-Cov(-1) virus and the disease it caused SARS (2002/2003). They are very similar, in fact, they are both not just corona viruses they are the same virus species and their diseases have very similar symptoms. However, SARS was deadlier but luckily not as contagious. He dedicates chapter seven to a comparison with pandemic and seasonal influenza. Some people tend to conflate seasonal and pandemic influenza. When a new influenza that no one has immunity against is introduced and spread around the world, that is a pandemic influenza. Examples are the Spanish flu in 1918, the 1957, 1968, and 2009 flu. Seasonal influenza is mutated/weakened versions of previous influenza and much less deadly than Covid-19. In terms of danger Covid-19 compares to a pandemic influenza. However, it is a completely different virus and the disease has different symptoms.
It is a relatively short book, but it has a lot of information. I learned something about Covid-19, viruses in general, the evolution of viruses, pandemics, influenza, genetics, and much more. I love learning interesting new things about how the world works and therefore I love this book. The book was well written, concise, well organized, and provided a lot of resources. Considering that there’s so much misinformation and disinformation circulating I think it is great to read something substantial from an expert and a researcher. Certainly, there is a lot we don’t know yet, but we should have a better understanding of what we do already know. Unfortunately, the print in the paperback is small and probably too small for some readers. Normally I would deduct a point for such an oversight, but I was able to read it and the book is so interesting that I give it five stars.
The first chapters include layperson introductions to epidemiology, coronaviruses and viral evolution, all in the context of the current pandemic. Following chapters describe the ongoing pandemic, and comparisons with the SARS outbreak and influenza pandemics. Last chapters discuss potential therapies, relevant unanswered questions and future perspectives.
Fascinating and enjoyable. Highly recommended!
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