This link on the Linksys UK site says that it is compatible with Vista http://www-uk.linksys.com/servlet/Satellite?c=L_Content_C1&childpagename=UK/Layout&cid=1169671172872&pagename=Linksys/Common/VisitorWrapper
Linux Wireless The Linux-based Wireless-G Linux Broadband Router was created specially for hobbyists and wireless aficionados. Add wireless capability to your wired network and enjoy the convenience that comes when you eliminate cables. Add wireless
Minimum Requirements Internet Explorer 6.0 or Firefox 1.0 or Higher for Web-based configuration. CD-ROM Drive, Windows 2000, XP, or Vista, Network Adapter or Wireless Network Adapter
Basically, any wireless system that uses the 802.11g standard (which is nearly any wireless-equipped computer today) will be compatible with this, or any other "g" router, regardless of the operating system one uses. For example, I use Windows XP, Vista, Linux, Mac OS X, an iPod Touch, and an HP wifi-enabled printer with my router and none of those systems have any problems connecting to the wireless network.