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Genome: The Autobiography of a Species in 23 Chapters Paperback – October 3, 2000
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“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker
The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future
Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.
Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
Review
“A fascinating tour of the human genome…If you want to catch a glimpse of the biotech century that is now dawning…GENOME is an excellent place to start.” — Wall Street Journal
“A superb writer whose exquisite, often moving descriptions of life’s designs remind me of the best work of the late Lewis Thomas. . . . He crafts some of the clearest explanations of complex biological processes that I have encountered. . . . He captures their slippery beauty.” — Washington Post Book World
“A tour de force: clear, witty, timely, and informed by an intelligence that sees new knowledge as a blessing and not a curse.” — London Times
“A jargon-free excursion of intellectual discovery that will carry any reader along its tour of exciting, often delightful, stories structured to help us understand in everyday terms, and to remember, the revelations about genetic evolution that have come to light in the last few decades. It also makes us see the enormous social and political consequences of that knowledge.” — New York Times Book Review
“Ridley is a lucid, engaging and enthusiastic guide to the double-helical DNA that comprises our inheritable human essence.” — Los Angeles Times Book Review
“An extraordinarily nimble synthesist, Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker
“Ridley can explain with equal verve difficult moral issues, philosophical quandaries and technical biochemistry; he distinguishes facts from opinions well, and he’s not shy about offering either. Among many recent books on genes, behavior and evolution, Ridley’s is one of the most informative. It’s also the most fun to read.” — Publishers Weekly (starred review)
“An engrossing account of the genetic history of our species. . . . This book will be particularly relevant to lay readers, providing insight into how far we have come and where we are heading in the understanding of our genetic heritage. — Library Journal
“A lucid and exhilarating romp through our 23 human chromosomes that lets us see how nature and nature combine to make us human.” — James Watson
“With riveting anecdotes, clever analogies and compelling writing, Matt Ridley makes the human genome come alive for us. I was left in awe at the wonder of the human body, and the scientists who unravel its mysteries.” — Abraham Verghese, author of The Tennis Partner
“Matt Ridley [writes] with a combination of biblical awe, scientific curiosity and wit about what many consider the greatest scientific breakthrough of the 20th century and the greatest technological challenge of the 21st: the discovery of the molecular basis of life and its many applications in medicine, law, and commerce.” — Dallas Morning News
“Thoroughly fascinating. . . . A sophisticated blending of science and public policy certain to educate, entertain, challenge and stimulate even the least technologically inclined reader.” — Philadelphia Inquirer
“Ridley is a lucid, engaging, and enthusiastic guide.” — Los Angeles Times Book Review
From the Back Cover
The genome's been mapped. But what does it mean?
Arguably the most significant scientific discoveru of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.
Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
About the Author
Matt Ridley is the author of books that have sold well over a million copies in 32 languages: THE RED QUEEN, THE ORIGINS OF VIRTUE, GENOME, NATURE VIA NURTURE, FRANCIS CRICK, THE RATIONAL OPTIMIST, THE EVOLUTION OF EVERYTHING, and HOW INNOVATION WORKS. In his bestseller GENOME and in his biography of Francis Crick, he showed an ability to translate the details of genomic discoveries into understandable and exciting stories. During the current pandemic, he has written essays for the Wall Street Journal and The Spectator about the origin and genomics of the virus. His most recent WSJ piece appeared on January 16, 2021. He is a member of the House of Lords in the UK.
- Print length352 pages
- LanguageEnglish
- PublisherHarper Perennial
- Publication dateOctober 3, 2000
- Dimensions5.31 x 0.79 x 8 inches
- ISBN-100060932902
- ISBN-13978-0060932909
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Product details
- Publisher : Harper Perennial; 1st edition (October 3, 2000)
- Language : English
- Paperback : 352 pages
- ISBN-10 : 0060932902
- ISBN-13 : 978-0060932909
- Item Weight : 9.8 ounces
- Dimensions : 5.31 x 0.79 x 8 inches
- Best Sellers Rank: #4,359,100 in Books (See Top 100 in Books)
- #740 in Developmental Biology (Books)
- #2,005 in Biotechnology (Books)
- #3,311 in Genetics (Books)
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About the author

Matt Ridley's books have been shortlisted for six literary awards, including the Los Angeles Times Book Prize (for Genome: The Autobiography of a Species in 23 Chapters). His most recent book, The Agile Gene: How Nature Turns on Nurture, won the award for the best science book published in 2003 from the National Academies of Science. He has been a scientist, a journalist, and a national newspaper columnist, and is the chairman of the International Centre for Life, in Newcastle, England. Matt Ridley is also a visiting professor at Cold Spring Harbor Laboratory in New York.
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For instance, the 'final' human genome sequence wasn't published until 2003 (the 'draft' was published in 2001.) However, genetics is such a fast-moving field, that any book on this subject is automatically out-of-date even as it is going to press. So read "Genome" and enjoy!
Ridley does not duck the ethical questions concerning the manipulation of the genome. His final four chapters on chromosomes 19, 20, 21, and 22 are labeled respectively: "Prevention;" "Politics;" "Eugenics;" and "Free Will." It is interesting to note that the inventor of DNA fingerprinting, Alec Jeffreys, believes every citizen's genetic information should be stored on a national data base, but for identification purposes only. It should not be used to store information about susceptibility to disease for fear that governments and insurance companies will use such data to discriminate against those of us who might be greater health risks because of our genetic profiles.
One of Ridley's recurrent themes (the capital letters are his) is that "GENES ARE NOT THERE TO CAUSE DISEASES." So if you do happen to have the gene for 'bad' blood lipids (see chromosome 19), you are not automatically doomed. In fact, the author argues very forcefully that this is the genetic information that you (not your insurance company) should know, so that you can take preventative life-style measures.
On the other hand, you may not want to know if you have the mutated version of the gene that causes Huntington's chorea (see the chapter on chromosome 4, entitled "Fate.")
One of the most heartening stories in "Genome" concerns the virtual elimination of cystic fibrosis in the American Jewish population: "The Committee for the Prevention of Jewish Genetic Disease organizes the test of schoolchildren's blood. When matchmakers are later considering a marriage between two young people, they can call a hotline and quote the two anonymous numbers" that the boy and girl received when they were tested. If both are carriers of the same mutation for cystic fibrosis (or Tay-Sachs disease), they are advised not to marry.
This policy seems to be working--why not expand this type of genetic testing to the whole population?
One small mistake should be noted. In the chapter on "Prevention" the author states that, "After Fleming found penicillin we were guilty of neglect if we failed to take a dying tubercular patient to the doctor." Actually penicillin is active only against Gram-positive bacteria and not against Gram-negative species, including 'Mycobacterium tuberculosis' (the cause of tuberculosis).
Other than the above, "Genome" is a very meaty introduction to a chordate in "a phylum that survived the Cambrian era 500 million years ago by the skin of its teeth in competition with the brilliantly successful arthropods." We are lucky to be here, and lucky to have our genetic story told by such an interesting writer.
Ridley does point out the success of the reductionist strategy in fighting cancer, and perhaps someday combating genetic diseases. He comes out positively in support of GMOs. Given that the population of the world will double in about forty years, if mankind is going to feed fourteen billion people, some great revolution in food production will be necessary. GMOs are one aspect of that revolution. But there is real reason to be concerned about how these artificial organisms will interact with the environment, and even perhaps our own bacterial microbiome. This cannot can be done effectively from a reductionist perspective.
Since DNA and proteins each depend upon each other for replication, it seems most probable that RNA, which is replicable in itself, is the first molecule in the formation of life. Ridley presents lots of fascinating information in an entertaining and easy to read style. Highly recommended, but take it with a grain of salt.
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Cada capítulo, encabezado por un potente titular y una cita, te engancha con fuerza.

