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Molecular Evolution Hardcover – July 1, 1997

by Wen-Hsiung Li (Author)

3 customer reviews

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This text describes the dynamics of evolutionary change at the molecular level, the driving forces behind the evolutionary process, and the effects of the various molecular mechanisms on the structure of genes and genomes. It also explains the methodology involved in dealing with molecular data.

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About the Author

WEN-HSIUNG LI, University of Chicago, USA. --This text refers to an out of print or unavailable edition of this title.

Hardcover: 487 pages
Publisher: Sinauer Associates Inc (July 1, 1997)
Language: English
ISBN-10: 0878934634
ISBN-13: 978-0878934638
Product Dimensions: 7.2 x 1.2 x 10.8 inches
Shipping Weight: 2.2 pounds
Average Customer Review: 3 customer reviews
Amazon Best Sellers Rank: #508,625 in Books (See Top 100 in Books)
- #134 in Books > Science & Math > Evolution > Organic
- #280 in Books > Science & Math > Biological Sciences > Biology > Molecular Biology
- #35102 in Books > Medical Books

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Amazon Customer

Best book on subject on market today.

January 17, 2001

Format: HardcoverVerified Purchase

This is a fabulous work. Well written, almost a page turner. I've read, or been reading, Protein Evolution by Laszlo Patthy and Molecular Evolution by Page and Holmes. These are good books, but left me wanting clarification and greater depth. I searched the UCSD BioMed Library and discovered Li's Molecular Evolution. Just what I was looking for. It's a nice improvement over the Principles of Molecular Evolution by Li and Graur. I note a new edition of the latter book is due out soon which makes me wonder if the new book might not be an update to Li's book. The only reason I didn't give the book 5 stars is the typography. The print and style of the earlier work by Li and Graur is far superior.

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Howard Schneider

Serious molecular evolution

November 26, 2000

Format: Hardcover

The general reader who has already read some other references on molecular methods will find this reference to be a reasonable to read yet fairly detailed, comprehensive overview of molecular methods used to discern evolutionary history. The reference begins with the fundamentals of gene structure and function, population genetics, and evolutionary changes in DNA sequences. The use of molecular methods to determine phylogenetic relationships between organisms is then discussed. Molecular clocks are discussed as well. Gene duplication is then discussed. This has been an important mechanism for generating new genes in the evolution of life on Earth. As well, duplication of portions of genes and subsequent 'exon shuffling' or 'domain shuffling', allows the emergence of proteins with new or improved functions. Concerted evolution, the phenomenon that DNA sequences of species evolve so that DNA sequences of the organism maintain similarities to each other, often being more similar internally than with homologous DNA sequences from related species, is then discussed. Gene conversion recombination and unequal crossing over are given as mechanisms for the phenomenon of concerted evolution. Transposable genetic elements are then discussed. Although there is controversy with regards to the effect that mobile genes have had on the evolution of life, they show that the genome is not a static structure, but is susceptible to evolutionary changes. Genome organization is then discussed. It is interesting to note that genome sizes of different bacteria is discontinuous, suggesting that genome duplication occurred in a variety of lineages, especially so 1.8 billion years ago when oxygen appeared in the atmosphere. The variation in genome size of eukaryotes is even greater than in bacteria, from 9 million base pairs in some fungi to 670,000 million base pairs in some diatoms (for reference, the genome size of E. coli bacteria is 4.7 million base pairs, that of humans is 3400 million base pairs), although the amniotes (ie, reptiles, birds and mammals) show much less variation in genome size. These results indicate that genome size itself only offers potential for complexity, as well as the implication that much of eukaryotic DNA does not code for anything. Other results also show that large amounts of eukaryotic DNA consists of repetitive segments. Mechanisms for the variation in eukaryotic DNA observed include genome duplication (although polyploidy is rare in animals reproducing via sex), chromosome duplications, transpositions, unequal crossing-over, and DNA amplification. The final chapter considers the selectionist-neutralist debate. Selectionists have a neo-Darwinian view of evolution, ie, there is genetic variability in the population which is changed by natural selection. The neutralists view evolution as being driven more by the rate of mutation than by selection.

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Matthew Fujita

Great and fast service.

February 18, 2013

Format: Hardcover

The book came faster than I expected! And it is in perfect condition. The book itself is out of a print so this is an invaluable addition to my library. Thank you!

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