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Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease and Inheritance Hardcover – September 1, 2011

by Nessa Carey (Author)

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'A book that would have had Darwin swooning - anyone seriously interested in who we are and how we function should read this.' Guardian At the beginning of this century enormous progress had been made in genetics. The Human Genome Project finished sequencing human DNA. It seemed it was only a matter of time until we had all the answers to the secrets of life on this planet. The cutting-edge of biology, however, is telling us that we still don't even know all of the questions. How is it that, despite each cell in your body carrying exactly the same DNA, you don't have teeth growing out of your eyeballs or toenails on your liver? How is it that identical twins share exactly the same DNA and yet can exhibit dramatic differences in the way that they live and grow? It turns out that cells read the genetic code in DNA more like a script to be interpreted than a mould that replicates the same result each time. This is epigenetics and it's the fastest-moving field in biology today. The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years. Biologist Nessa Carey deftly explains such diverse phenomena as how queen bees and ants control their colonies, why tortoiseshell cats are always female, why some plants need a period of cold before they can flower, why we age, develop disease and become addicted to drugs, and much more. Most excitingly, Carey reveals the amazing possibilities for humankind that epigenetics offers for us all - and in the surprisingly near future.

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Editorial Reviews

Review

'Nessa Carey takes us on a lively and up-to-date tour of what's known about epigenetic mechanisms and their implications for ageing and cancer.' -- BBC Focus 'A book that would have had Darwin swooning - anyone seriously interested in who we are and how we function should read this book.' -- Guardian '[A] splendidly clear explanation' -- Colin Berry * The Oldie * `Fascinating stuff.' -- Bookseller `A hugely compelling explanation of the very latest from the frontline of modern biology ... The Epigenetics Revolution traces the thrilling path this discipline has taken over the last twenty years.' -- Waterstones `This is a readable book that applies scientific theory to the everyday world.' -- Bookseller 'Her book combines an easy style with a textbook's thoroughness.' -- Nature 'Sees DNA as a film script, with plenty of room for interpretation and retakes. Carey's experience of the biotechnology industry shows in her concluding remarks on the pros and cons of our growing understanding of epigenetics for drug discovery, and on understanding the impact of diet and environment on disease.' -- Nature 'An exhilarating exploration of an exciting new field, and a good gift for a bright biology student looking for a career choice.' -- Kirkus Review

About the Author

Nessa Carey has a PhD in virology from the University of Edinburgh and has worked in the biotech industry for nearly ten years.

Hardcover: 320 pages
Publisher: Icon Books (September 1, 2011)
Language: English
ISBN-10: 184831292X
ISBN-13: 978-1848312920
Product Dimensions: 6 x 1.6 x 8.5 inches
Shipping Weight: 1.3 pounds
Average Customer Review: 158 customer reviews
Amazon Best Sellers Rank: #4,325,767 in Books (See Top 100 in Books)
- #903 in Books > Computers & Technology > Computer Science > Bioinformatics
- #4453 in Books > Medical Books > Basic Sciences > Genetics
- #18229 in Books > Medical Books > Medicine > Internal Medicine > Pathology > Diseases

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Herbert Gintis

Challenging, well written, authoritative

August 5, 2015

Format: PaperbackVerified Purchase

This is a fine introduction to the topic by an extremely knowledgeable researcher. Carey tries to make it all very accessible to the novice, but in fact it presupposes a fair amount of understanding of molecular biology, especially of how DNA and RNA work, and at least a rudimentary understanding of protein folding and heredity.
I felt there was too great an emphasis on epigenetic causes of human diseases, about which fairly little is known (except for a few rare but well-explored cases). Therefore, I only skimmed the last few chapters.
I read this book and also took a Coursera online course in epigenetics, but I still have no clear idea about the relationship between genetics and epigenetics as applied to inheritance patterns. I cannot imagine how to add epigenetic dynamics to the biological models I work with, or if they make any difference at all to population biology.

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Sitka

Great introduction to epigenetics

July 11, 2017

Format: PaperbackVerified Purchase

This is my first book on Epigenetics and it’s fascinating how different situations, actions, or experiences in our lives can affect our cells. Events that happened to our parents, grandparents, and so forth can also affect our cells in ways science is just starting to understand. I liked how Nessa Carey laid out the book. She starts with a history and some examples of epigenetics. She then discusses cells and how they work and how epigenetics is contributing to understanding diseases such as cancer and Alzheimer’s. She looks at why identical twins are not truly identical at the cellular level and how psychological trauma at an early age can affect us. She finishes the book with what we can expect to see in the future from the field of Epigenetics.

I learned a lot from this book and want to learn more about this topic. I did find it difficult to stay engaged, partly because of Carey’s abundant use of adverbs, and partly because I’m not well versed in biology. Maybe if I had a better basic understanding before going in – it’s been a long time since I took a college biology course – it would’ve been more engaging for me. Overall a great introduction to the field.

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BattleBornMom

Overall, an excellent read.

June 11, 2018

Format: PaperbackVerified Purchase

If you are looking for a comprehensive introduction to the science of epigentics, this will serve you well. It was a relatively easy and enjoyable read.

The criticism of its intended audience being unclear is fair. At times, it seems to be aimed at a rather lay audience with slightly odd analogies that over simplify almost to a fault. A few pages later, jargon and technicalities are tossed around that definitely require a solid background in biology to follow with any ease. This has the discordant effect of making the simplistic analogies seem even more odd. It can’t seem to decide if it expects you to remember only basic high school biology or if it prefers you’ve had at least a couple of undergraduate level courses in molecular biology and genetics.

That being said, it was incredibly helpful in updating my understanding of this field. As a biology major in the ‘90s, this field was so nascent that it was barely addressed, let alone studied thoroughly. As a teacher of AP Bio in high school today, I needed an update on vertebrate gene regulation in order to be able to competently address the topic in my classroom. This book provided exactly that. While I won’t be teaching most of the advanced details in this book, I will be adjusting a few critical things to ensure alignment with today’s knowledge.

Even better, it reminded me why I have always found genetics so fascinating. It’s even more so now than it was 25 years ago. As so often happens in emerging fields, each intriguing answer leads to dozens more questions. If you think the way a basic prokaryotic operon works is pretty cool, learning about mammalian epigenetic gene regulation will make your brain geek out with intellectual joy.

6 people found this helpful

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Amazon Customer

Good on principles, light on molecules

December 28, 2014

Format: PaperbackVerified Purchase

Very nicely written layman level intro to Epigenetics. Great analogies, good exposition, good emphasis about explaining why discoveries are important are unexpected.

Read it as an informal textbook to an academic class in Epigenetics. Probably got 33% of all the learning from the book and 67% from the class, and I have a suspicion the the basic lessons of the book will stick more than the forest of class details about what protein acetylates what unit of the histone.

Would possibly be nice to expose a little more of the molecular detail, without frightening horses and small children.

15 people found this helpful

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laura

Excellent book, changes your original way of thinking about your DNA

August 19, 2017

Format: Kindle EditionVerified Purchase

I had to read excerpts from this book for a graduate level biology class. I was so interested in learning more about how epigenetics is changing our understanding of inheritance that I had to purchase it and read more. This should be required reading for all "older" biology teachers. Highly recommended!

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ane

I have enjoyed the book, and I would definitely recommend it to novices and experts.

November 19, 2013

Format: PaperbackVerified Purchase

I have enjoyed the book, and I would definitely recommend it to novices and experts. I am a DNA methylation professional, I work on molecular mechanism of DNA methylation. I bought the book to have one place reference for the phenotypic aspects of epigenetics. I think that the author did an excellent job of balancing the text for different types of readers. The author gives the names of the researchers that did some key discoveries, so the interested reader can always go to google.scholar and pubmed for the original publications. The simple language, numerous comparisons and explanations makes this book readable to the people without expertise in epigenetics, but also to an average graduate with BSc degree.

The book is not for people interested in molecular aspects of DNA methylation, but it does not need to be, since such text would not be for a wide audience. My only critique would be that the author should add few more figures, that could make the text bigger pleasure to read and browse. If there are about 10 more drawings in the text I would give it full five stars. I have no doubt that with rapid development of epigenetics, this book will come in newer editions. With few additional drawings, it will be a five star read. One missing figure could be changes in DNA methylation through embryonic development and gametogenesis. Congratulations to the author, Cheers to all readers.

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