We adopted our 3 legged, 70-75lb Dobie after he had his leg removed at 6 years old. A 12 year old dog is going to have aches and pains let alone a 3 legged one! For the last year, he has been on a small dose of prednisone to help him walk; however, the last 2 months, the prednisone hasn't been working as well. While we doubled the prednisone to help alleviate his pain, he was still having trouble getting up/down & around. Being familiar with the ingredients combined with the positive reviews, I decided to give these chews a try. SO glad we did. It seemed to help our Doberman the first 24 hours. Four days later, we knew the chews were helping our Dobie. We went down to his regular small dose of prednisone and he began acting "lively" (almost puppy-like), is getting up and down more easily, walking/hopping around and more engaged with us again. The biggest test was going for a walk. I was unable to take him around the median in our neighborhood (a 3 minute walk) without his leg repeatedly giving out just 1 week prior. Five days in with the chews, we took him on a 10 minute walk where he continued to go up & down inclines. The last 2 minutes of the walk he needed assistance (Definitely overdid the first walk. The next day, he was once again improved.) We are stocking up on this one & would recommend it to anyone with a dog having trouble getting up/down & around. Note: on dosing: for a 70 lb dog, they recommend 4 chews. We don't give them all at once - We give 2 chews in am & 2 chews in pm.