This is all new to me. A run-down condition, resulting in a visit to my Nutritionist, produced a diagnosis of a B12 deficiency for which she prescribed Apex Energetics B12-Max, a “Methyl-B12” to take orally. I also left there with a bottle of that which she recommends for methylation issues. She mentioned it should also help with some mysterious inflammation of joints because of its analgesic properties. I felt very comfortable with this because tests have shown it has significant benefits in lowering levels of LDH, total cholesterol, triglycerides, homocysteine, and a range of gut and other issues. She has rarely been wrong in guiding my health decisions with the use of natural methods, herbs, etc. instead of using chemicals. When I ran out, I looked to replace it on Amazon, but couldn't. I found this and bought it because it uses a “Methyl-B12” and so it held me over the time I needed to take it.