Our Veterinarian is awesome about product evaluation--she chooses the best, not the most expensive. That being said, our dog is 10 years old and was have rear leg stiffness. The doctor checked her out and thought it might possibly be an ACL tear (yikes!). It was not a tear. The Vet placed her on dog Motrin and suggested the use of Nutramax Dasuquin Chews with MSM. The cost at the office was $69 and she wanted our dog to take a loading dose of 2 in the morning and 2 at night for 30 days then go down to 1 in the morning and 1 at night. She also told us that the product was less expensive on Amazon, which it was/is! We noticed after two weeks of just the Dasuquin that she was moving like her old self and back to going for walks (her favorite activity!). We had run out and went a week or two before reordering--she started limping again--next day order! We do not miss orders anymore and, in fact, we are putting this on auto-ship monthly. She also loves the chews as a treat. Win/win and a no brainer to keep our dog pain free. Dog Motrin is similar to human Motrin--lower dose, but similar side effects--we didn't want our dog on it but for a few days. She is active, when it suits her, with no stiffness. Great product!