I have one, and purchased one on Amazon for my wife just prior to a 2-week trip to Europe. She gave me a seriously skeptical look while packing (using packing cubes, of course), but found that pretty much everything needed fit. A few bulky items (down sweater) and computer, packed in a small backpack. Checked the bag internationally, and used as a carry-on in Europe (no, this isn't the smaller "euro-size") without issue, on both planes and helicopters. Each bag proved worthy, without showing any wear from the animals who act as baggage handlers.
We travel somewhat frequently, and on this trip, we were in a similar climate the entire time, so no need for 2 types of outer wear or extra warm clothes. It's not for packing dress clothes, but for convenient grab-and-go trips.
Definitely recommend. And, Osprey's guaranty is comforting in case there are issues.