These made my dog REALLY sick. He's a minpin/toy poodle mix and almost immediately after starting him on these his stomach started getting VERY upset. He was throwing up a lot and just sitting down on walks which is so unlike him. I thought maybe he needed an adjustment period so I persisted but he got worse. I finally just gave up when he decided to stop eating all together. Not like him at all and it was very upsetting to see.