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Life Extension Melatonin 6 Hour Time Release - 300 mcg - For Sleep Quality, Hormone Balance, Immune Function and Anti-Aging - Gluten-Free, Non-GMO - 100 Vegetarian Tablets

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1,021 ratings

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SLEEP SOUNDLY – Melatonin promotes healthy sleep/wake patterns and encourages onset and quality of sleep, and supports morning alertness and overall quality of life.
SUPPORTS WHOLE BODY HEALTH – Melatonin helps support circadian rhythms and immune function, promote cellular and DNA health, as well as helps inhibit oxidative stress and protect mitochondria.
ALL NIGHT SUPPORT – By releasing 300mcg of melatonin over an extended period of time, our Melatonin 6 Hour Timed Release formula makes it easier for you to fall asleep and stay asleep.
INGREDIENTS MATTER - Sourced using only the finest raw ingredients with the purity and potency your body deserves. The majority of our products are non-GMO, gluten-free, and manufactured in the USA—and a Certificate of Analysis is available for every product we produce.
LIVE YOUR HEALTHIEST LIFE - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. Our formulations are created using the ingredients and dosages used in the studies that inspired them, ensuring that maximum bioavailability and efficacy is achieved.

Note: Products with electrical plugs are designed for use in the US. Outlets and voltage differ internationally and this product may require an adapter or converter for use in your destination. Please check compatibility before purchasing.

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$11.99 ($0.06/Count)
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From the manufacturer

Product Description

Melatonin increases the speed of falling asleep and promotes sleep quality. It also has strong antioxidant properties and is important for protecting cellular DNA.2,3 And our Melatonin 6 Hour formula releases 300 mcg of melatonin gradually to help you stay asleep. More Facts About Melatonin 6 Hour Timed Release : Melatonin is a hormone derived from the amino acid tryptophan. Melatonin is primarily synthesized by your pineal gland and released mostly at night. In addition to healthy sleep support, melatonin has been shown to support immune health, healthy brain function and more. Melatonin and sleep : A good night's sleep is crucial for overall health and well-being. But many people experience difficulty falling asleep and staying asleep. Healthy sleep patterns are governed by your body's circadian rhythm and proper melatonin secretion is essential to maintaining a healthy circadian rhythm. But melatonin release declines with age and can be affected by jet lag, shift work and more. Melatonin promotes healthy sleep/wake patterns and encourages onset and quality of sleep, and fosters morning alertness and overall quality of life. Melatonin and oxidative stress : Melatonin is especially important for healthy cellular DNA and mitochondria support because it helps inhibit oxidative damage. Melatonin does this more effectively than many other antioxidants. Melatonin and immune health : Melatonin has a beneficial impact on the immune system. It can activate immune response when more is necessary, but also help restrain overactive immune response. This combined effect is known as modulation, making melatonin a true immune supporter. Melatonin and cognitive health : Melatonin has shown a strong relationship with promoting cognitive health. Melatonin supplementation has been shown in clinical trials to help support healthy cognitive function.

Product details

Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 2 x 2 x 4 inches; 1.6 Ounces
Item model number ‏ : ‎ 01787
Date First Available ‏ : ‎ April 15, 2013
Manufacturer ‏ : ‎ Life Extension
ASIN ‏ : ‎ B00CDABRUW

Best Sellers Rank: #15,759 in Health & Household (See Top 100 in Health & Household)
- #147 in Herbal & Nutritional Sleep Supplements
- #154 in Sleep & Snoring Aids
- #2,138 in Sales & Deals

Customer Reviews:
1,021 ratings

Important information

Safety Information

This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Melatonin 300 mcg, Other ingredients: microcrystalline cellulose, hydroxypropyl methylcellulose, hydroxypropylcellulose, aqueous film coating (purified water, hydroxypropyl methylcellulose, glycerin), stearic acid, vegetable stearate, croscarmellose sodium, silica.

Directions

Take one (1) tablet 30 to 60 minutes before bedtime, or as recommended by a healthcare practitioner. Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

Legal Disclaimer

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Customer reviews

4.3 out of 5

1,021 global ratings

5 star		65%
4 star		15%
3 star		10%
2 star		3%
1 star		6%

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Top reviews from the United States

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Slice

stuff works

Reviewed in the United States 🇺🇸 on December 12, 2022

Verified Purchase

If your circadian rhythm is off this will absolutely help. Its slow release function helps prevent you from waking up in the middle of the night. Highly recommend this product

Helpful

Rudy W. Maich

This is Not USP-Verified Melatonin

Reviewed in the United States 🇺🇸 on January 5, 2019

Verified Purchase

I emailed the company that makes this melatonin product ("Quality Supplements and Vitamins, Inc.", dba, "LifeExtension"), twice, after purchasing and receiving this product, and discovering that no source was given on the bottle for the melatonin used in the product. They responded with what I would call a "public-relations"-type letter that did not, in my opinion, address my concerns. It appears to me that they intentionally tried to "snow" me with misleading statements that did not respond to my questions.

They attached a copy of their "COA" for this product that indicates that they perform tests for bacterial, fungal and heavy-metal contamination. This is probably sufficient, I believe, for testing samples of botanical materials, but is insufficient, I believe, for the testing of melatonin, or other drugs - which manufactured melatonin is. Melatonin, or any drug, should, in my opinion, be tested for purity and chemical contamination (which is the whole purpose of using "USP verified" materials). They argued, essentially, that because they are not required to do this by law, that it was unnecessary and just a marketing gimmick - I would say a very-good marketing gimmick.

They emphasized that they comply with "current Good Manufacturing Practices", which is a good thing, but is, in my opinion, misleading in this instance, as cGMP will do nothing to prevent the use of impure and chemically-contaminated drugs that may be used in compounding a product - even without the manufacturer's knowledge.

A pharmaceutical-grade compound is "a drug, biologic, or reagent that is approved by the Food and Drug Administration (FDA) or for which a chemical purity standard has been established by the United States Pharmacopeia-National Formulary (USP-NF) or British Pharmacopeia (BP)." Melatonin, as a manufactured product, is a drug. It is not "unfortunate" that some manufacturers meet this standard. In my opinion, if a company's melatonin does not meet this standard, it should not be sold for human consumption. Researchers, performing studies with animals normally require this standard for the products they use, to prevent the harming of their test animals. It is shocking, to me, that a company would show less concern to their customers, than researchers show to their test animals.

Consumer Reports states: "When you purchase any melatonin product (or any other dietary supplement, for that matter), make sure to look for the “USP verified” label. This seal indicates that the product has been subject to voluntary testing and meets US Pharmacopeia Convention standards (meaning the product is accurately labeled and free of harmful substances)."

Consumer Reports further states:

"Researchers from the University of Guleph in Ontario, Canada, tested 31 different melatonin supplements from 16 different brands. ... Here’s what they found:

"The actual melatonin content of those products ranged from 83% less to 478% more than the amount advertised on the label, with most products (21 out of 31) failing to fall within 10% of the label claim."

"Variability within individual products was also high; some products differed by as much as 465% in their melatonin content from one package to the next."

"Eight of the tested products also contained serotonin, a by-product of melatonin degradation that has its own medicinal effects and risks associated with overuse."

"... for most people, serotonin poses an even bigger risk. It's possible to overdose on very low levels of this chemical, the study's authors write. The condition is known as “serotonin syndrome,” and can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures)."

I do not know if this company's product was included in this test - it may not have been, but the whole point is, if USP-verified melatonin is not used, we have no way of knowing if it is safe for consumption. If this company complies with cGMP standards, it would suggest that there should be uniformity from pill to pill in the dosage present, and that they have not themselves contaminated the product during the manufacturing process, but the quality and safety of the melatonin included is still not addressed.

This may be one great product, but without independent certification (through USP verification} of the melatonin they use, we have no way to know this. I've tossed my bottle in the trash to be safe, even though I am not one that likes to waste my money.

If what I've read on the internet is true, a lot of unsafe, even dangerous, drugs and chemicals are being manufactured in third-world countries, and imported to the United States for use by the largely-unregulated supplement industry. With so many companies, today, making the maximization of profits their only concern, why should anyone trust any manufacturer who considers the independent verification of the purity of the ingredients they use in their products as unimportant?

399 people found this helpful

Helpful

300 mcg of time released Plus I take regular 300 mcg combined

Reviewed in the United States 🇺🇸 on March 13, 2022

Verified Purchase

This 300 mcg is fine, but I take them with either 300 mcg regular melatonin or half of a 1 mg tablet, and combined they work for me. This way I can get some time-released melatonin in my system for the entire night and some of the regular to get to sleep sooner. This by itself doesn't work for me, it's too little, that's why I need to add the others. I have tried this brand's 750 mcg of time-released and it works much better than 300 mcg. But with melatonin less is more, otherwise, it can have an opposite effect and keep me up instead of putting me asleep. 1 mg is plenty for anyone, anything more can have side effects and cause sleep problems

5 people found this helpful

Helpful

emory2001

Excellent, But With It Was 8 Hour Time Release

Reviewed in the United States 🇺🇸 on May 30, 2015

Verified Purchase

The best sleep aid I've found, after trying a few different things.

Long before I started having sleep problems recently, I've used the Tempur-Pedic sleep eye mask for 12 years, to block out all light when I sleep (highly recommend to add to your sleep regimen). I always wanted to make sure my sleep was the highest quality, with no light. So I was kind of surprised when I suddenly began having insomnia about 6 months ago - waking once or twice in the night, then waking at 4 a.m. "ready for the day." I'm a fan of supplements, but I've tried enough of them through the years to know I usually can't handle something strong. And of course I didn't want anything that could be addictive, because this was happening every single night, not just an "occasional" sleepless night. So I started with gentle herbal supplements and teas like chamomile, lavender, passion flower, and lemon balm. No valerian sleep aids for me, because I have a paradoxical reaction to it (instead of calming me, it gives me the opposite - anxiety and racing heartbeat). The herbs helped me relax but didn't help me sleep.

I was hesitant to try melatonin because it's a hormone, and I've had my hormones messed up before, but I was desperate for sleep. I suspected the 3 mg and 5 mg doses on the market would be way too much. I started with a 1.5 mg supplement, which worked but I woke up groggy and nauseous. Too much. I tried a few lower dose options (not time released like this one), which helped me fall asleep and eliminated the first night wakings, but I still woke up at 4 a.m. on the dot and couldn't go back to sleep.

Clearly I needed the melatonin to stay in my system longer, so it occurred to me to look for a time released option (which, oddly, didn't come up in my searches for melatonin until I searched specifically for time released). This looked like a good option. 1 tablet worked pretty well at keeping me asleep until about 5 a.m., which was an improvement, but it took longer for me to fall asleep in the first place because the small dose is distributed so slowly. 2 tablets are PERFECT for me at 600 mcg (equivalent to 0.6 mg, just over half a milligram, distributed evenly throughout the night). I had the most glorious night of sleep I've had in 6 months.

I like this Life Extension one because it's such a tiny dose, I don't have to cut it and I was able to double up easily, without going over 1 mg. If you needed 3 tablets, it would still be less than 1 mg. With such a small dose, you can make these fine-tune adjustments. Hormones are very powerful and delicate like that. There's no reason to go overboard with them. I definitely recommend this.

UPDATE: I do wish this was an 8 hour time release instead of 6. I sleep great through the 6 hours, but I'm wide awake as soon as it wears off. All the current research says adults need 8 hours of sleep for optimal health. I get by, but I NEED another two hours of sleep each night.

224 people found this helpful

Helpful

Bjorncloud

Makes me very groggy if I take it too late

Reviewed in the United States 🇺🇸 on October 9, 2020

Verified Purchase

Now I know this is a smaller dose than what most people take, but I am used to taking 300 mcg so it works well. My issue with these time release ones is that they make me very groggy if I take them too late. So I try and take them about an hour before bed and only if I am going to get 8 hours of sleep. Maybe I metabolize melatonin slower than other people? I am not sure, but I have tried it over 10 times and get that same effect if I take it too close to sleeping.
I personally really enjoyed the chewable 300 mcg melatonin but they seemed to have stopped making the one I had been previously taking. Anyway it works good for me to help me fall asleep a bit faster but I just have to time it correctly- you may not experience the same problem but it is worth noting just in case.

8 people found this helpful

Helpful

Alberta

DEEP SLEEP

Reviewed in the United States 🇺🇸 on July 17, 2022

Verified Purchase

This product offers just the right amount of melatonin. This is a hormone and people tend to take too much of it. My doctor told me to take 330 micrograms. It builds up and works better with time. Plus, it's time-release so it keeps on giving.

4 people found this helpful

Helpful

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Life Extension Melatonin 6 Hour Time Release - 300 mcg - For Sleep Quality, Hormone Balance, Immune Function and Anti-Aging - Gluten-Free, Non-GMO - 100 Vegetarian Tablets

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