My wife is undergoing continuing chemotherapy for breast cancer, and will take the oral medication as long as it continues to hold back the cancer. One of the side effects of the medicine is "hand/foot syndrome" which causes the palms of the hands and soles of the feet to get very red, sore, peel, crack, etc. Recently she began applying AQUAPHOR liberally to her hands and feet, then putting on plastic gloves on her hands, and her feet into Zip-Lock baggies followed by socks to hold the baggies on. Within 10 days her hands and feet were markedly better. She can now walk without severe pain, and no more cracks in the soles of her feet.