Dasuquin was recommended by my vet, and it works very well. I got my dog off of prescription anti-inflammatories in less than a week. Of course, this is not a miracle cure and when she overdoes it, her limp and stiffness reappear for a few days. However, they do not seem to be as pronounced nor as long lasting as they were before she started on the Dasuquin. After she was on these for about six months, I wanted to see if the difference was real or coincidental. I decided that when I ran out, I wouldn't buy more right away. I noticed a reappearance of her limp and increased stiffness after she was off them for a few weeks, which tells me they do make a difference. I deducted one star because they do dry out after a while and my dog didn't want to eat them. I decided to try the chewable tablets for my 2nd purchase, but she doesn't like them anywhere near as much as she liked these. I will just buy the smaller bag of the soft chews when I need more. For reference, my dog is about 10 years old and 75#. She has grade 1-2 tears in both ACLs and accompanying arthritis in the early stages. Some additional information per my vet: Dasuquin is made by an American company, the same company that makes Cosequin for humans. They use high quality ingredients and make the supplements in the US. They specifically guarantee the bioavailability of their ingredients. Bioavailability refers to the amount of a particular ingredient actually available to be used by the body. What many people don't realize is that many vitamins, minerals and supplements are formulated in the cheapest way possible, which means that the body may or may not be able to make use of it. For example, there may be 5000 mg of glucosamine in a tablet, but the body may only be able to absorb 300 mg because it is too difficult to process. Buying cheap supplements that have high dose levels does no good if it can't be absorbed by the body. Buying a more expensive supplement with a seemingly lower dosage but higher bioavailability actually provides the body with more of the key ingredient(s) than a cheaper supplement with lower bioavailability does.