This trade collects Amazing Spider-Man issues # 617-621 and material from Web of Spider-Man #3 and 4.
So far The Gauntlet has been a very weird "event." The connectivity of Spider-Man's encounters is entirely behind the scenes. With both Spider-Man and the villains he's facing unaware of the manipulative forces at work the stories really don't feel like they form a cohesive whole.
On the other hand, the stories themselves have been very good. This trade features two of my favorites. We get a surprisingly fantastic character study featuring Rhino, followed by a layered game of smoke and mirrors involving Mr. Negative, the mafia, and Mysterio. Interspersed are origin stories for each of the titular villains.
The Rhino story is short but relatively deep with some nice "twists" and great characterization. Mysterio's longer arc is complicated, but well told and one of the most interesting uses of the character I've read. The origins are decent little side-bars.
So overall a great collection of stories part of a bafflingly off the mark crossover event. Recommended, with or without any other Gauntlet trades.