Obviously I have no way of knowing what qualifies as small to you and I'm not familiar with audio cords intended for computers. Are they the size of RCA cables?
I use two of these devices with external HDD enclosures with no issues. My eSATA, USB3 and FW800 cables slot in great. Obviously the thicker cords cause bending of the spacers but I'd imagine this was part of the design.
My only disappointment is that they're JUST heavy enough to keep a full compliment of larger cables from compromising stability. If they were another 3 ounces I'd have no concerns. Consequently, I try to keep them an inch or two away from the edge of my desk.