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Customer Review

457 of 510 people found the following review helpful
1.0 out of 5 stars Don't be deceived, February 24, 2009
This review is from: Prevagen Apoaequorin, 30-Count Bottle (Health and Beauty)
I do scientific (not medical) research on the proteins which are contained in this supplement, and there is no reason that this product, a calcium-binding protein, will help you.

As they are legally required to say on their own web site: "This product is not intended to diagnose, treat, cure or prevent any disease." Their "research" consists of cells in a culture dish and has no relation to human mental acuity. In the past, the creators have tried to mislead people into thinking that this is the jellyfish protein that won the Nobel Prize in 2008 (it's not). The lies do not end there: the "testimonials" on their site come from easily found stock photos (unless the same people are also fluent in French and also concerned about Italian osteopathy -- aah, the irony).

If you ingested EDTA or another calcium-binding chemical, it would be more effective at pulling calcium from your bloodstream than this protein. Proteins will not cross the blood-brain barrier, and they will largely be digested before leaving your system, releasing any calcium they might have bound. Even if this product *did* work to remove calcium, in the age groups that they are targeting, you should probably be taking calcium *supplements* and not trying to leach it out of your system. My grandfather died of complications from a broken hip, and he is not the only one.

Please do not be fooled.
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Showing 1-10 of 27 posts in this discussion
Initial post: May 22, 2009 12:21:14 PM PDT
boxermom51 says:
I went to the Nobel 2008 info and found this info on the prize for Chemistry: At UCSD, Tsien's lab began improving and exploiting a green fluorescent protein from Aequorea victoria, a jellyfish that glows brightly in the dark. He and his collaborators also created variants of the protein with other colors. Introducing this molecule or its variants into a cell made it possible to follow all kinds of biochemical processes within living cells `in real time' - they are literally made visible.

So apparently it is the same jellyfish, just not the same application. I am willing to give this a try based on others recommendations.

Posted on Jul 7, 2009 6:36:36 PM PDT
KB41 says:
Guy sounds more like a disgruntled ex-employee than a REAL researcher!

Posted on Oct 1, 2009 5:56:58 AM PDT
K. Larsen says:
Sounds like a good counter argument to consider. Another site ( on the web, pointed out a similar concern about calcium in older folks... i found both of these because I was researching Prevagen for my dad. No matter what the claims on a product, from a computer mouse to a supplement, good or bad I like to look for additional info before buying. I think the real jury is out right now. $45 is a bit pricey for a test dad is losing his short term memory in an unsettling way. He seems unaware that he is not making sense and is getting angry at those around him. If I end up trying it with him, will let you know what happens. Right now, i do not think I'm convinced this is the solution.

Posted on Oct 17, 2009 8:28:03 AM PDT
Jerry Snyder says:
I have not heard that this product will, as you say, "leach" calcium from the body. According to "love to know vitamins" (dot com site) :

Aequorin is classified as a photo protein that is isolated from luminescent jellyfish. It was discovered in 1960 and has been used in research for a long time as a Calcium indicator. However, now there is some very preliminary research that suggests this ingredient may help with neurodegenerative diseases. While the exact causes of diseases like Alzheimer's is not necessarily known, there have been links between this disease and the loss of Calcium binding proteins that protect nerve cells. According to scientists, Calcium is necessary for communication between neurons located in the brain, and it is not possible to learn or maintain memory without Calcium.

This is where Aequorin comes in. Some early, inconclusive research suggests that this Jellyfish derivative is a viable substitute for the Calcium binding proteins that naturally decline with age. However, it is not quite yet known if this theory is accurate, so tests on this ingredient are still being conducted.

Posted on Jan 17, 2010 12:25:03 PM PST
Richard M says:
Beroe may do "scientific research" as he states, but there is a VAST difference between scientific and medical research. Scientific research could include anything from analyzing tires to checking the molecular makeup of the dirt in your back yard. His credentials are specious at best and without any merit in this particular area. His opinions are simply his opinions and nothing more.

Posted on Mar 5, 2010 8:12:43 AM PST
Catherine says:
Experience is the best teacher. It helps me w/ mental sharpness, creativity and word recall.

In reply to an earlier post on Apr 13, 2010 4:39:55 PM PDT
B. Reilly says:
K. Larsen, I read your post about possibly trying Prevagen with your dad--did you end up trying it? I'm looking for something like this to help my dad's memory, too (wouldn't hurt for me to take something, too!) Please let me know if it helped.

In reply to an earlier post on Apr 14, 2010 5:45:15 AM PDT
K. Larsen says:
I decided against it. I felt way to much of the positive word on the product is generated by the company and its promoters. Felt too suspicious about the company. Taking higher daily doses of omega-3's has been beneficial to me.

In reply to an earlier post on Sep 16, 2010 6:21:02 AM PDT
Omega-3's are good. Must get the right kind. Fermented cod liver oil may be worth looking into. Have you tried high dose Turmeric? Look into it. New Chapter TurmericForce may be the best. I may also look into Jarrow's Brain Optimizer. A mulitfacted approach is needed with diet as well. Digestive enzymes are critical to help absorb all the nutrients from food. Best I know of is Digest Gold. OmegaZyme is good too

In reply to an earlier post on Sep 16, 2010 6:33:18 AM PDT
Richard M says:
If you want Omega 3. The best I have found is made by Sisel Intl in Springville, Utah. I personally use it daily and am very pleased with it.
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