I am 26 and have been dealing with IBS-D since I was 18. I have seen many different doctors & tried many different approaches to help in reducing my symptoms. As there is no real cure for IBS, I obviously hadn't had much luck with many of these approaches such as antispasmodics, increased fiber, etc. My only quick fix relief would come from taking Immodium. As many IBS sufferers experience, it has significantly altered my quality of life over the years from avoiding certain social functions to even avoiding food altogether. The hardest part was having to watch other people, such as my boyfriend, also constantly having to deal with "my stomach issues" as a result of needing to flee from different places once an episode set in. There didn't seem to be any rhyme or reason to when an episode would occur...sometimes just thinking about having to eat while outside the comfort of my home would bring one on. Yet, certain foods such as coffee, dairy, and alcohol would almost always trigger an episode. As a teacher, I'm not able to use the bathroom whenever needed, so I tried Align after reading the positive reviews here. (I did try Digestive Advantage first, but with little success.) I am currently on week four & I am feeling better then I have ever felt before. I started having one, normal BM a day within four days of taking align & the urgency to constantly have to go within seconds of eating has subsided. I have progressively been getting better with each day-with only some bloating the first several days. In the past 4 weeks, I only had one flare up & many of my trigger foods have caused me no trouble. I know that IBS is some how affected by our body's response to our nervous system, so it can not necessarily "cure" that mental aspect of IBS..you'll need to build confidence in the product and what it does. I would absolutely tell you to try this product if you are an IBS-D sufferer. It just may work in reducing your symptoms and giving you back a better quality of life like it has done for me. I wouldn't normally go out of my way to write something like this...but I feel it is important for people to see this because I know just how debilitating IBS can be for many.